C. Ren

A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome

The paper identifies a Pseudomonas aeruginosa VgrG2b fragment cleaved by caspase-11 that inhibits NLRP3 inflammasome activation, promoting infection and improving survival with a specific peptide inhibitor.

DNA sensor ABCF1 phase separates with cccDNA to inhibit HBV replication

This study identifies ABCF1 as a host protein that interacts with cccDNA, forming phase-separated condensates to suppress HBV replication through innate immune activation and transcription inhibition.

A benchmarked comparison of software packagesfor time-lapse image processing of monolayerbacterial population dynamics

The paper benchmarks four time-lapse image processing software packages for analyzing bacterial population dynamics using E. coli data, finding performance differences across packages and highlighting deep learning's advantage in segmentation over tracking.

Dense Sampling of Taxa and Genomes Untangles the Phylogenetic Backbone of a Non-model Plant Lineage Rife with Deep Hybridization and Allopolyploidy

The paper constructs a robust phylogenetic backbone for the Campanuleae tribe using genomic data and phylogenetic methods, revealing hybridization and allopolyploidy as key drivers of diversification.

Antimicrobial peptides modulate lung injury by altering the intestinal microbiota

The paper shows that antimicrobial peptides (AMPs) in the intestine modulate lung injury by altering the microbiota in response to hyperoxia.

Identification and Characterization of CtUGT3 as the Key Player of Astragalin Biosynthesis in Safflower

This study identifies CtUGT3 as the key UGT enzyme responsible for astragalin biosynthesis in safflower through metabolomics, transcriptome analysis, and biochemical experiments.

Nightmare or delight: taxonomic circumscription meets reticulate evolution in the phylogenomic era

The paper investigates reticulate evolution in the genus Stranvaesia using phylogenomic data, revealing how hybridization and allopolyploidy influence taxonomic classification and leading to the description of a new genus.

Platelet Activating Factor Activity Modulates Hyperoxic Neonatal Lung Injury Severity

This study investigates the role of platelet activating factor (PAF) signaling in hyperoxic neonatal lung injury and BPD by comparing WT and PAF receptor knockout mice.

Three-dimensional imaging and quantification of mouse ovarian follicles via optical coherence tomography

This study uses SD-OCT to identify and quantify ovarian follicles in mice, showing agreement with histology and improved image contrast for follicle analysis.

Targeted genome editing in grape using multiple CRISPR-guided editing systems

This study evaluates CRISPR/Cas9, CRISPR/LbCpf1, and base editors for targeted genome editing in grape, showing variable efficiencies and PAM specificity.

JQ-1 ameliorates schistosomiasis liver granuloma in mice by suppressing male and female reproductive systems and egg development of Schistosoma japonicum

This study shows JQ-1 reduces liver granuloma size and egg production in Schistosoma japonicum-infected mice by inhibiting reproductive system development and gene expression.

Phylogenomic analyses in the apple genus Malus s.l. reveal widespread hybridization and allopolyploidy driving the diversifications, with insights into the complex biogeographic history in the Northern Hemisphere

A high throughput bispecific antibody discovery pipeline

This paper introduces a high throughput single-cell pipeline for bispecific antibody discovery, demonstrating its efficiency in identifying rare functional clones and uncovering design principles for improved immunotherapeutics.

Capturing single-copy nuclear genes, organellar genomes, and nuclear ribosomal DNA from deep genome skimming data for plant phylogenetics: A case study in Vitaceae

This study evaluates optimal sequencing depth for recovering single-copy nuclear genes from genome skimming data and shows deep genome skimming can effectively capture these genes alongside other genomic features.

JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activation

This study shows JQ-1 reduces liver fibrosis in Schistosoma-infected mice by inhibiting JAK2/STAT3 signaling in hepatic stellate cells.

Isolation and characterization of Streptomyces bacteriophages and Streptomyces strains encoding biosynthetic arsenals

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.

Targeted genome editing in Nicotiana tabacum using inducible CRISPR/Cas9 system

This study develops an estrogen-inducible CRISPR/Cas9 system in Nicotiana tabacum and demonstrates its efficacy in inducing targeted mutagenesis of the NtPDS gene.

B1a cells protect against Schistosoma japonicum-induced liver inflammation and fibrosis by controlling monocyte infiltration

This study shows that B1a cells reduce liver inflammation and fibrosis in Schistosoma japonicum infection by secreting IL-10, which suppresses monocyte infiltration and inflammatory cytokines.