G. Morgan

Structure and dynamics of human cardiac fibroblast nanotubes

This study examines the structure and dynamics of cardiac fibroblast nanotubes in human atrial tissue and cell lines, showing their role in intercellular communication and ECM interaction.

Impact of rare structural variant events in newly diagnosed multiple myeloma

This study examines rare structural variants in multiple myeloma patients, showing their association with gene expression changes and potential role in disease pathogenesis.

Chemotherapy Signatures Map Evolution of Therapy-Related Myeloid Neoplasms

The paper reconstructs the evolutionary history of therapy-related myeloid neoplasms using chemotherapy-associated mutational signatures and identifies distinct mutational patterns linked to different chemotherapies.

Whole genome sequencing provides evidence of two biologically and clinically distinct entities of asymptomatic monoclonal gammopathies: progressive versus stable myeloma precursor condition

The paper uses whole genome sequencing to identify two distinct myeloma precursor conditions, progressive and stable, based on genomic features.

Accelerated single cell seeding in relapsed multiple myeloma

This study uses whole genome sequencing to show that relapsed multiple myeloma exhibits accelerated systemic seeding driven by chemotherapy-induced mutations and clonal expansion of single myeloma cells.

Multiple Myeloma DREAM Challenge Reveals Epigenetic Regulator PHF19 As Marker of Aggressive Disease

The paper identifies PHF19 as a marker of aggressive multiple myeloma and shows a simple four-feature model performs as well as complex gene expression models.

A lumenal interrupted helix in human sperm tail microtubules

The paper uses cryo-ET to discover a novel left-handed interrupted helix in human sperm tail microtubules, named TAILS, which binds to protofilaments and may stabilize microtubules or control swimming.