J. J. Zhao

This study identifies vitcylation, a novel vitamin C-derived protein modification, and shows it enhances STAT1-mediated immune response by inhibiting PTPN2 interaction and increasing IFN pathway activation in tumor cells.

This paper introduces a novel EGFR-TKI, CM93, which shows improved brain penetration and efficacy against EGFR-mutated glioblastoma in vitro and in vivo.

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.