Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
7 papers
Recent·Most cited
H. Belda, D. Bradley, E. Christodoulou, S. D. Nofal, M. Broncel, D. A. Jones, H. Davies, M. T. Bertran, A. G. Purkiss, R. W. Ogrodowicz, D. Joshi, N. O'Reilly, L. Walport, A. Claessens, A. Powell, , M. Treeck
This study investigates the evolution and inhibition of FIKK kinases in P. falciparum, showing they can be inhibited by a single compound.
bioRxiv · Feb 22, 2024 · PreprintMicrobiology
E. J. Carr, H. Townsley, M. Y. Wu, K. A. Wilkinson, P. S. Hobson, D. Levi, S. Namjou, H. V. Mears, A. Hobbs, M. Ragno, L. S. Herman, R. Harvey, C. Bailey, A. S. Fowler, E. Hatipoglu, , E. C. Wall
The paper identifies four patterns of SARS-CoV-2 vaccine responses, including broad and narrow responders, and links broad responder traits to longer infection-free time after vaccination.
bioRxiv · May 24, 2023 · PreprintImmunology
C. Basier, R. Beale, G. Bineva-Todd, B. Canal, J. F. Curran, T. D. Deegan, J. F. Diffley, R. Fujisawa, M. Howell, D. Joshi, K. Labib, C. T. Lim, J. Milligan, H. Nagaraj, N. O'Reilly, , T. U. Zeisner
This study identifies small molecule inhibitors of SARS-CoV-2 nsp5 main protease, finding calpain inhibitor I and peptidyl fluoromethylketones with potent antiviral activity.
bioRxiv · Apr 7, 2021Biochemistry
L. A. Armstrong, R. Beale, G. Bineva-Todd, B. Canal, J. F. Diffley, L. S. Drury, M. Howell, Y. Kulathu, K. Labib, C. T. Lim, J. Milligan, N. O'Reilly, E. Ozono, K. W. Tan, R. Ulferts, , J. Zeng
This study identifies two small molecule inhibitors of SARS-CoV-2 Nsp3 PLpro that inhibit viral replication in cell culture.
bioRxiv · Apr 7, 2021Biochemistry
O. Belan, C. Barroso, A. Kaczmarczyk, R. Anand, S. Federico, N. O'Reilly, M. D. Newton, E. Maeots, R. I. Enchev, E. Martinez-Perez, D. S. Rueda, S. J. Boulton
The paper uses single-molecule imaging to show how BRC-2 and RFS-1/RIP-1 mediate RAD-51 filament nucleation and growth during homologous recombination.
bioRxiv · Nov 5, 2020Biophysics
S. Lynham, F. Grundland Freile, N. M. Puri, N. O'Reilly, G. H. Mitchell, T. Wells, M. Willcox, R. Beatson
The paper identifies chlorophyll a-b binding protein AB96 as a plant-derived protein that binds to active TGFbeta1, suggesting potential therapeutic applications.
bioRxiv · Aug 20, 2020Immunology
K. W. Ng, N. Faulkner, G. Cornish, A. Rosa, R. Harvey, S. Hussain, R. Ulferts, C. Earl, A. Wrobel, D. Benton, C. Roustan, W. Bolland, R. Thompson, A. Agua-Doce, P. Hobson, , Mc
The paper identifies pre-existing and de novo humoral immunity to SARS-CoV-2 in humans, showing that uninfected individuals have SARS-CoV-2 S-reactive antibodies, particularly in children, and that infection leads to higher antibody titres targeting multiple subunits.
bioRxiv · May 14, 2020Immunology