M. Simons

Dietary restriction extends lifespan across different temperatures in the fly

This study re-tests dietary restriction's effect on fly lifespan across different temperatures, finding robust lifespan extension regardless of temperature.

Lethal COVID-19 Associates With RAAS-Induced Inflammation For Multiple Organ Damage Including Mediastinal Lymph Nodes

This study identifies non-canonical genes linked to RAAS overactivation in lethal COVID-19, causing multi-organ damage and mediastinal lymph node dysfunction.

A highly resolved network reveals the role of terrestrial herbivory in structuring aboveground food webs

The paper constructs a high-resolution terrestrial aboveground food web revealing unique structural properties of herbivory and carnivory interactions.

Stochasticity explains non-genetic inheritance of lifespan and apparent trade-offs between reproduction and ageing

The paper shows that stochastic effects explain non-genetic lifespan inheritance and apparent trade-offs between reproduction and ageing in Drosophila.

Rapamycin not Dietary Restriction improves resilience against pathogens: a meta-analysis

This paper compares the effects of rapamycin and dietary restriction on post-infection survival in mice using meta-analysis, finding rapamycin improves survival while DR reduces it.

Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation

The paper uses multi-omics and 3D-imaging to show that calvaria bone marrow has a distinct molecular profile and contributes to neuroinflammation.

Increasing triacylglycerol formation and lipid storage by unsaturated lipids protects renal proximal tubules in diabetes

This study shows that unsaturated lipids reduce renal damage in diabetes by increasing lipid storage and protecting against ER stress in proximal tubular cells.

MEKK3-TGFβ crosstalk regulates inward arterial remodeling

This study identifies endothelial MEKK3 as a regulator of inward arterial remodeling through TGFβ-Smad2/3 signaling, leading to hypertension and atherosclerosis.

Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients

The paper identifies PS+ PMPs as a marker for disease severity in COVID-19 by showing their correlation with immune dysfunction and clinical outcomes.

Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system

This study shows that neuropilin-1 enhances SARS-CoV-2 infectivity and facilitates viral entry into the central nervous system via the olfactory pathway.

In vivo identification of apoptotic and extracellular vesicle-bound live cells using image-based deep learning

This paper introduces a method using fluorescent MFG-E8 and deep learning to identify apoptotic and EV-bound live cells in vivo, finding that most PS+ cells are live cells associated with EVs.

Activation of Smad 2/3 signaling by low shear stress mediates artery inward remodeling

This study shows that low shear stress activates Smad 2/3 signaling in endothelial cells, leading to inward artery remodeling.

Ageing in house sparrows is insensitive to environmental effects

This study shows that house sparrows exhibit similar mortality senescence in wild and captive settings, but lower frailty in captivity, suggesting species-specific ageing rates insensitive to environment.