R. Ye

Structural insights into agonist binding and activation of succinate receptor 1

This study presents cryo-EM structures of SUCNR1-Gi complexes bound to succinate and epoxysuccinate, revealing key residues and structural changes involved in agonist binding and activation.

Structure-Aware Dual-Target Drug Design through Collaborative Learning of Pharmacophore Combination and Molecular Simulation

AIxFuse generates dual-target drugs by learning pharmacophore fusion patterns that satisfy structural constraints from molecular docking, outperforming existing methods in success rate and binding free energy.

Terpenoid balance in Aspergillus nidulans unveiled by heterologous squalene synthase expression

The paper shows that expressing a heterologous squalene synthase from Pseudogymnoascus destructans in Aspergillus nidulans alters terpene biosynthesis, increasing squalene and new nidulenes while reducing austinol.

Three-dimensional microenvironment regulates gene expression, function, and tight junction dynamics of iPSC-derived blood-brain barrier microvessels

This study shows that a 3D microenvironment enhances BBB phenotype and function in iPSC-derived microvessels compared to 2D cultures.

The S1/S2 boundary of SARS-CoV-2 spike protein modulates cell entry pathways and transmission

This study shows that the S1/S2 boundary of the SARS-CoV-2 spike protein affects cell entry and transmission by altering the pathway used for viral entry.

Membrane Insertion of MoS2 Nanosheets: Fresh vs. Aged

This study compares the interaction of fresh and aged MoS2 nanosheets with lipid membranes, finding that fresh nanosheets have stronger binding affinity.

ATM-deficient lung, prostate and pancreatic cancer cells are acutely sensitive to the combination of olaparib and the ATR inhibitor AZD6738

This study shows that ATM-deficient cancer cells are more sensitive to the combination of olaparib and AZD6738, leading to cell death.