Heparan sulfate dependent phase separation of CCL5 and its chemotactic activity
X. Yu, G. Duan, P. Pei, L. Chen, R. Gu, W. Hu, H. Zhang, Y.-D. Wang, L. Gong, L. Liu, T.-T. Chu, J.-P. Li, S.-Z. Luo
This study shows that CCL5 and heparan sulfate form phase-separated gradients, which guide immune cell migration, and demonstrates this through in vitro and in vivo experiments.
bioRxiv · Nov 15, 2023Cell Biology