L. Gong

The paper investigates how vegetation types affect bacterial and fungal community assembly in soil, finding that abundant taxa are mainly controlled by stochastic processes while rare taxa differ in their drivers.

This study shows that INHBA/activin A suppresses IFN-γ signaling, leading to resistance to anti-PD-L1 therapy and promoting tumor growth.

This study shows that CCL5 and heparan sulfate form phase-separated gradients, which guide immune cell migration, and demonstrates this through in vitro and in vivo experiments.

This study characterizes viral diversity and host interactions in deep-sea hydrothermal vents, revealing novel viral lineages and metabolic roles in host adaptation.

The paper identifies the re-emergence of SADS-CoV in pigs in Guangxi, China, through qPCR and metagenomic analysis, suggesting undetected circulation since 2019.

This study shows that suppressing CMTM6 in tumors or hosts enhances anti-tumor immunity independently of PD-L1, suggesting CMTM6 as a target for gene therapy.

This paper reports chromosome-level genome assemblies of five Sitopsis species and identifies the B-subgenome donor of bread wheat as an extinct species closely related to Ae. speltoides.

This study shows that blocking the sympathetic nervous system reduces fasting-induced liver fat accumulation by suppressing CD36 upregulation.

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

This study shows JQ-1 reduces liver granuloma size and egg production in Schistosoma japonicum-infected mice by inhibiting reproductive system development and gene expression.

This study develops an aging clock based on blood transcriptome data to assess aging rates and evaluate rejuvenation treatments like NMN and Metformin.

This study investigates how homoeologous exchange affects gene expression and alternative splicing in synthetic allotetraploid wheat, finding cis- and trans-regulatory impacts on gene expression and AS events.

This study identifies BcPTP1 as a phytotoxic effector secreted by Botrytis cinerea during late infection, which induces cell death and promotes lesion spreading.

The paper develops a PD-L1 and TLR7 dual-targeting nanobody-drug conjugate that synergistically activates innate and adaptive immune responses, showing potent antitumor effects in both 'hot' and 'cold' tumors.

This study identifies CD147 as a novel receptor for SARS-CoV-2 spike protein, showing that Meplazumab inhibits viral entry with EC50 24.86 g/mL and confirms the interaction through binding assays and microscopy.

This paper develops a yeast biosensor to detect chlorothalonil and heavy metals toxicity, showing improved sensitivity through optimized culture conditions and morphological, ROS, DNA, and caspase 3 activity analysis.

The paper compares ATP bioluminescence and colony counting methods for evaluating disinfection effectiveness and finds poor correlation between methods, suggesting ATP may not be suitable for disinfection evaluation.