A. Diwan

Chimeric Antigen Receptor Macrophages Target and Resorb Amyloid Plaques in a Mouse Model of Alzheimer's Disease

This paper demonstrates that CAR-Ms engineered to secrete M-CSF can target and reduce amyloid plaques in a mouse model of Alzheimer's disease.

Dual Effects of NV-CoV-2 Biomimetic Polymer: An Antiviral regimen against COVID-19

This paper evaluates NV-CoV-2 polymer and its encapsulation of remdesivir (NV-CoV-2-R) for antiviral efficacy against COVID-19, showing improved stability and effectiveness compared to remdesivir alone.

Nanoviricides platform technology based NV-CoV-2 polymer increases the half-life of Remdesivir in vivo

This paper reports on a non-clinical study of NV-CoV-2 polymer and its encapsulation of Remdesivir, showing improved in vivo stability and safety in rats.

Nanoviricides Platform Technology based NV-387 polymer Protects Remdesivir from Plasma-Mediated Catabolism in vitro:Importance of its increased lifetime for in vivo action

The paper demonstrates that encapsulating remdesivir with the NV-387 polymer enhances its stability in plasma in vitro, potentially improving its in vivo efficacy.

TRAF2, an innate immune sensor, reciprocally regulates mitophagy and inflammation to maintain cardiac myocyte homeostasis.

This study shows TRAF2 regulates mitophagy and inflammation in cardiac myocytes to prevent cell death and maintain homeostasis.

Single-cell transcriptome profiling reveals multicellular ecosystem of nucleus pulposus during degeneration progression

This study uses single-cell transcriptomics to identify novel cell populations and functional differences in human nucleus pulposus during degeneration, revealing potential regenerative and immunosuppressive roles.

Apolipoprotein M attenuates anthracycline cardiotoxicity and lysosomal injury

This paper investigates the role of apolipoprotein M in anthracycline cardiotoxicity, finding that ApoM protects against cardiac dysfunction and lysosomal injury through the autophagy-lysosome pathway.