Author

Y. Ai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:development & morphogenesis· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

C. Guo· 2 shared S. Gould· 2 shared X. Wang· 2 shared Z. Zhang· 2 shared A. Cox· 1 shared A. Pekosz· 1 shared A. Saftics· 1 shared B. Dong· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

C. Guo

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

J. Wang, Z. An, Z. Wu, W. Zhou, P. Sun, P. Wu, R. Xue, S. Dang, X. Bai, W. Wang, R. Chen, Y. Du, P. Huang, S. M. Lam, Y. Ai, , K. He

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

bioRxiv · Jul 5, 2024Cell Biology

Syntenin and CD63 Promote Exosome Biogenesis from the Plasma Membrane by Blocking Cargo Endocytosis

Y. Ai, C. Guo, M. Garcia-Contreras, L. S. Sanchez, A. Saftics, O. Shodubi, S. Raghunandan, J. Xu, S.-J. Tsai, Y. Dong, R. Li, T. Jovanovic-Talisman, S. Gould

This study shows that syntenin and CD63 promote exosome biogenesis by blocking CD63 endocytosis, allowing it to accumulate at the plasma membrane where exosomes originate.

bioRxiv · May 26, 2023Cell Biology

Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat generated by CRISPR/Cas9

M. Wang, Y. Qi, Y. Cao, X. Zhang, Y. Wang, J. Zhang, Q. Liu, Q. Zhou, Y. Ai, S. Wei, L. Wang, G. Liu, Z. Lian, H. Han

This study generates genetically engineered goats expressing a domain fusion TLR2-4 receptor to enhance autophagy-dependent clearance of Staphylococcus aureus in macrophages.

bioRxiv · Mar 10, 2022Immunology

The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike

C. Guo, S. J. Tsai, Y. Ai, M. Li, A. Pekosz, A. Cox, N. Atai, S. Gould

This study shows the D614G mutation in SARS-CoV-2 spike enhances lysosomal trafficking and accumulation, contributing to increased infectivity and transmission.

bioRxiv · Dec 8, 2020Cell Biology

Casein Kinase 1G2 Suppresses Necroptosis-Promoted Testis Aging by Inhibiting Receptor-Interacting Kinase 3

X. Wang, D. Li, Y. Ai, J. Guo, B. Dong, L. Li, G. Cai, S. Chen, D. Xu, F. Wang

This study shows that CSNK1G2 inhibits RIP3-mediated necroptosis, reducing testis aging in mice and conserved in humans.

eLife · Nov 18, 2020Peer-reviewedCell Biology

Oxidoreductases generate hydrogen peroxide that drives iron-dependent lipid peroxidation during ferroptosis

B. Yan, Y. Ai, Z. Zhang, X. Wang

This study identifies POR and CYB5R1 as oxidoreductases that generate hydrogen peroxide, driving iron-dependent lipid peroxidation and ferroptosis.

bioRxiv · Aug 1, 2020 · PreprintBiochemistry