Author

S. L. Nutt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 7 Research Focus:cell type annotation· 6 Assay:bulk RNA-seq· 4 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

M. J. Davis· 3 shared A. P. Ng· 2 shared C. Alvarado· 2 shared C. W. Tan· 2 shared J. R. Groom· 2 shared J. Rautela· 2 shared K. Rogers· 2 shared L. Dalit· 2 shared

Activity by Year

2019-2024 · peak 3/yr

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10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

M. J. Davis

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Author profile →

7 papers

Recent·Most cited

Transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection

B. J. Broomfield, C. W. Tan, R. Z. Qin, B. C. Duckworth, C. Alvarado, L. Dalit, J. Chen, L. Mackiewicz, H. Muramatsu, M. Pellegrini, K. Rogers, W. J. Moon, S. L. Nutt, M. J. Davis, N. Pardi, , J. R. Groom

This paper shows that temporarily blocking type I interferon during viral infection boosts CD8+ T cell memory and vaccine effectiveness by promoting TSCM cell formation.

bioRxiv · Jun 26, 2024Immunology

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

L. Dalit, C. W. Tan, A. A. Sheikh, R. Munnings, C. Alvarado, T. Hussain, A. Zaini, L. Cooper, A. Kirn, L. Hailes, A. Nguyen, L. Mackay, N. Harris, C. Zaph, N. L. La Gruta, , J. R. Groom

The paper identifies transcriptional modules and cytokine signaling pathways that drive functional heterogeneity in T follicular helper cells across different infections.

bioRxiv · Jun 12, 2024Immunology

BATF controls IFN I production via DC-SCRIPT in plasmacytoid dendritic cells

S. Ali, R. Mann-Nüttel, M. Marson, B. Leiser, J. Hoffe, R. J. Dress, M. H. Bhuyan, P. Petzsch, K. Köhrer, H. C. Xu, P. A. Lang, S. Zhang, M. Chopin, S. L. Nutt, J. Alferink, S. Scheu

The paper shows BATF suppresses IFN I production in pDCs via DC-SCRIPT, revealing a negative feedback loop in antiviral immunity.

bioRxiv · Jan 11, 2024 · PreprintImmunology

CIS calibrates GM-CSF signalling strength to regulate macrophage polarization via a STAT5-IRF8 axis

s. zhang, J. Rautela, N. G. Bediaga, T. Kolesnik, Y. You, L. Dagley, J. Bedo, H. Wang, L. Sun, R. Sutherland, E. Surgenor, N. Iannarella, R. S. Allan, F. Souza-Fonseca-Guimaraes, Y. Xie, , Y. Zhan

This study identifies CIS as a regulator of GM-CSF signaling that controls macrophage polarization via the STAT5-IRF8 axis, influencing immune responses and allergic inflammation.

bioRxiv · Mar 31, 2022 · PreprintImmunology

Dysregulation of PAX5 causes uncommitted B cell development and tumorigenesis in mice

B. Boast, K. Helian, D. Andrews, X. Li, V. Cho, A. Closa, H. J. Sutton, J. H. Reed, H. Bergmann, C. M. Roots, M. Yabas, N. Barthel, S. A. Omari, C. Young, L. A. Miosge, , A. Enders

Reduced PAX5 function in mice leads to uncommitted B cell development and B-ALL with secondary mutations in Jak3 and Ptpn11.

bioRxiv · Jan 29, 2021 · PreprintImmunology

The clonal and molecular aetiology of emergency dendritic cell development

D. S. Lin, L. Tian, S. Tomei, D. Amann-Zalcenstein, T. M. Baldwin, T. S. Weber, J. Schreuder, O. Stonehouse, J. Rautela, N. D. Huntington, A. P. Ng, S. L. Nutt, S. Taoudi, M. E. Ritchie, P. D. Hodgkin, S. H. Naik

This study investigates Flt3L-driven emergency dendritic cell development, revealing clonal expansion and molecular mechanisms in HSPCs leading to cDC1 generation.

bioRxiv · May 28, 2020 · PreprintImmunology

An Erg driven transcriptional program controls B-lymphopoiesis

A. P. Ng, H. D. Coughlan, S. Hediyeh-zadeh, K. Behrens, T. M. Johanson, M. S. Y. Low, C. C. Bell, O. Gilan, Y.-C. Chan, A. J. Kueh, T. Boudier, L. DiRago, C. D. Hyland, H. Ierino, S. Mifsud, , W. S. Alexander

This study identifies Erg as a critical transcription factor initiating B-lymphopoiesis by regulating gene networks essential for B-cell development and V(D)J recombination.

bioRxiv · Dec 3, 2019 · PreprintImmunology