D. Shen

Down regulation of Engase in Caenorhabditis elegans may improve its stresses adaptivity

This study shows that downregulating CeEngase in C. elegans enhances its adaptability to heat and osmotic stress.

YamOmics: A comprehensive data resource on yam multi-omics

YamOmics compiles and organizes multi-omics data from 41 yam species, providing genomic, transcriptomic, and plastomic data along with variant and expression information for yam research and breeding.

Nodule organogenesis in Medicago truncatula requires local stage-specific auxin biosynthesis and transport

This study shows that auxin biosynthesis and transport genes are dynamically expressed during nodule formation in Medicago truncatula, creating auxin gradients essential for nodule development.

Apoplastic barrier establishment in roots and nodules of Lotus japonicus is essential for root-shoot signaling and N-fixation

This study identifies the role of apoplastic barriers in Lotus japonicus roots and nodules, showing their necessity for nitrogen fixation and root-shoot signaling.

Identification and characterization of a beta-1,4 Galactosidase from Elizabethkingia meningoseptica and its application on living cell surface

This study identifies and characterizes a beta-1,4 galactosidase from Elizabethkingia meningoseptica that can remove galactose from living cell surfaces, named geGalaseI.

Plant immunity activated and suppressed by a conserved effector protein family in mirid bug Riptortus pedestris

RPH1, a conserved HAMP in herbivorous insects, activates plant PTI responses, but R. pedestris evolved four paralogs to suppress this immunity.

Root barrier surveillance mechanisms convey soil nitrogen status to shoots

This study rewires root barrier formation to investigate the role of the Schengen pathway in conveying soil nitrogen status to shoots and its impact on root microbiome and plant growth.

Molecular and structural characterization of lenalidomide-mediated sequestration of eIF3i

This study identifies the structural basis of lenalidomide-mediated eIF3i sequestration and links it to antiangiogenic effects and cellular phenotypes.

Universal mechanism of hormone and allosteric agonist mediated activation of glycoprotein hormone receptors as revealed by structures of follicle stimulating hormone receptor

The paper reports cryo-EM structures of FSHR in inactive and active states, revealing a conserved activation mechanism and the role of H6157.42 in agonist selectivity.

Molecular Epidemiology and Microbiological Characteristics of Cryptococcus gattii VGII isolates from China

This study analyzes C. gattii VGII isolates from China using MLST and WGS, revealing genetic diversity and virulence differences, with no drug resistance observed.

A novel Phytophthora sojae effector PsFYVE1 modulates transcription and alternative splicing of immunity related genes by targeting host RZ-1A protein

This paper identifies PsFYVE1, a novel effector from Phytophthora sojae, which modulates plant immunity by altering transcription and alternative splicing of immunity-related genes through interaction with host RNA-binding proteins.

Single Cell Raman-Deuterium Isotope Probing for Drug Resistance of Elizabethkingia spp.

This study uses single cell Raman-DIP to rapidly determine antimicrobial susceptibility of Elizabethkingia spp. and confirms minocycline and levofloxacin as first-line treatments.

Cytoplasmic and nuclear Sw-5b NLR act both independently and synergistically to dictate full host defense against tospovirus infection

This study shows that the tomato NLR Sw-5b acts in both cytoplasm and nucleus to provide full resistance against tospovirus by blocking different infection stages.

Structural basis for repurpose and design of nucleoside drugs for treating COVID-19

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

Prediction and Characterization of RXLR Effectors in Pythium Species

This paper identifies and characterizes 359 RXLR effectors in nine Pythium species, revealing evolutionary patterns and functional roles in host interactions.

Promotion of hyperthermic-induced rDNA hypercondensation in Saccharomyces cerevisiae

This study investigates hyperthermic-induced rDNA hypercondensation in yeast, finding Hsp90 and Hmo1 play distinct roles in this process.

Nitrate inhibition of nodule formation in Medicago truncatula is mediated by ACC SYNTHASE 10

This study shows nitrate inhibits nodule formation in Medicago truncatula by reducing ACC SYNTHASE 10 expression, linking ethylene biosynthesis to nitrate's regulatory effect on nodulation.