W. Guo

This study identifies TIGAR as a driver of metabolic remodeling in ESCC, showing that targeting the glutamine pathway improves therapeutic outcomes in TIGAR-overexpressed tumors.

This paper introduces NIPSS, a nanopore sequencing method for direct miRNA sequencing, demonstrating single-molecule resolution and potential applications in cancer diagnostics and therapeutics.

The paper shows that loss of Glypican5 enhances Shh distribution through the extracellular matrix by reducing sequestering molecules, while Ext1 deficiency impairs Shh secretion.

The paper presents the structure of human TRPC6 ion channel in complex with inhibitor BTDM, revealing its architecture and inhibition mechanism.