W. Guo

This paper identifies the molecular mechanism of Jin Ning Fang's anti-lung cancer effect using network pharmacology and experimental validation, revealing key targets and compounds involved.

The paper shows that ECM dimensionality affects actin tension, which in turn modulates endoplasmic reticulum function and spheroid resilience in mammary epithelial cells.

This study compares the in vitro antifungal activity of SHR8008, a novel tetrazole, to itraconazole and fluconazole against Candida and Cryptococcus species, finding SHR8008 to be significantly more potent.

This study constructs high-resolution spatial transcriptomes of primary liver cancers to analyze spatial architecture and identify tumor microenvironment features.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

This study shows topical camostat mesylate inhibits SARS-CoV-2 infection in human airway cells, suggesting it could be used for pre- or post-exposure prophylaxis.

This study identifies ZmLBD5 and ZmLBD33 as class II LBD genes in maize that regulate gibberellin and abscisic acid biosynthesis, affecting plant growth and drought tolerance.

This study shows sulfur limitation increases duckweed starch yield without reducing growth, making it a promising method for biofuel production.

This study shows that SETD7 methylates KRAS at lysine 182 and 184, promoting its degradation and suppressing RAS/MEK/ERK signaling, thereby acting as a tumor suppressor in NSCLC.

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

This study uses cryo-electron tomography to compare 3D subcellular structures of wild-type and mutagenic Chlorella pyrenoidosa strains, revealing structural changes linked to increased growth rates.

This study shows HuR promotes NASH by enhancing DR5/caspase8/caspase3-mediated hepatocyte death through stabilizing DR5 mRNA.

The paper identifies ERG's role in prostate cancer by showing it inhibits basal cell differentiation through chromatin interactions, promoting luminal cell fate.

This study shows that Zika virus-based immunotherapy improves long-term survival in mice with brain tumors by boosting memory T-cell levels.

The paper uses intravital imaging to show macrophage-induced cancer stem cells (CSCs) are enriched at TMEM doorways during metastasis, with CSCs comprising >60% of circulating tumor cells.

This study identifies phosphorylated residues in RBM20, showing their role in splicing control and protein shuttling, and links their mutation to cardiac dysfunction.

This paper develops a S1-Fc vaccine targeting antigen-presenting cells, showing it elicits protective anti-SARS-CoV-2 IgG and T cell responses, with high protection at low doses.

The paper uses RNA-seq and ATAC-seq to show that both SRMI and IRMI increase chromatin accessibility at defense genes, revealing overlapping transcriptional regulatory mechanisms.

This study shows that culturing murine BMSCs under hypoxia reduces hematopoietic contamination and increases stromal cell population.

The paper identifies HaRxL21, an oomycete effector, and shows it interacts with TPL to suppress plant immunity and promote pathogen susceptibility.

The paper shows that lateral mechanical impedance, not frontal, promotes cortical expansion and radial growth in maize roots.

This study uses cryo-electron tomography to show that the C-ring of Vibrio alginolyticus undergoes structural remodeling during rotational switching.

The paper determines cryo-EM structures of human TRPC5 channel with two inhibitors, revealing their distinct binding sites and mechanisms of action.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

The paper modifies phosphorylation sites of the Cre1 transcription factor in Trichoderma reesei to enhance cellulase production under glucose repression.

This study investigates how ammonium accumulation from nitrogen and carbon metabolism imbalance inhibits growth in Methylomonas sp. ZR1 and identifies strategies to mitigate this inhibition.

The paper uses single-cell RNA sequencing to analyze immune cell composition in brain metastases of NSCLC patients, finding reduced T cell activity and expanded M2-polarized tumor-associated macrophages.

Easy MPE automates microplot extraction from UAV images, achieving 91% average IOU accuracy compared to manual methods.

This study shows that longer double-stranded RNAs accumulate more in plastids, leading to stronger RNAi effects against Colorado potato beetle larvae.