cell-cell communication

This paper introduces split-1POK, a split protein tape monomer that enables scalable, spatiotemporally resolved recording of cellular calcium dynamics and molecular interactions over time.

The paper compares aging and obesity effects on visceral adipose tissue, finding aging drives more pronounced senescence and intercellular signaling impairments than obesity.

The paper examines oscillatory network directionality in the human medial temporal lobe during verbal working memory tasks, finding reversed directional patterns across encoding and retrieval phases.

The paper identifies ciliated keratinocytes as a pro-inflammatory cell state in psoriasis and atopic dermatitis, showing their association with disease activity and response to treatment.

This study introduces Perturb-Tags, a spatial multi-omic technique for CRISPR screening, revealing non-autonomous gene expression changes and spatial organization shifts in human embryoid bodies.

Chimera measures gene expression deployment across species, showing differences between predicted and observed expression patterns, revealing new insights beyond sequence conservation.

This study shows that SOX7 and ERG reprogram human pluripotent stem cell-derived cells into brain endothelial cells with forebrain regional bias, improving BBB modeling.

This paper introduces xGL-APMS to profile endogenous galectin-3 interactions at the cell surface, identifying 125 interactors on Jurkat cells and 69 on mouse thymocytes.

This paper introduces RIDGE, a deconvolution framework that generates spatially continuous cell-type maps of the human cortex, revealing both global organization and regional specialization.

This paper identifies a universal AT2 cell marker, NaPi2b, and introduces upifitamab, a humanized monoclonal antibody, enabling cross-species AT2 cell isolation with high purity.

This study compares tumor-immune-stromal communication in plasmacytoid urothelial carcinoma (PUC) and conventional urothelial carcinoma (CUC) using single nucleus RNA sequencing and spatial transcriptomics, identifying distinct signaling patterns and potential therapeutic targets.

This paper introduces stochprofIC, an algorithm for noise-corrected state variability inference in single cells, validated using mini-bulk data from mouse brains and human breast cancers.

This study develops MosaicoidX to analyze MECP2 mosaicism in human cortical organoids, revealing spatial organization and functional connectivity differences between wild-type and mutant cells.

The paper identifies molecular and physiological differences between asymptomatic Alzheimer's disease brains and Alzheimer's disease brains that correlate with cognitive resilience.

CellVocal links spatial context to transcriptional dynamics by integrating spatial RNA velocity with cell-cell communication to attribute cell-state transitions to signalling modules and neighbouring cells.

CellChat Hotspot improves the interpretability of cell-cell communication networks by integrating gene set enrichment and context-driven filtering, identifying recurrence-associated patterns in colon cancer.

This study maps viral RNA signals across cell types and tissues in colorectal cancer, identifying significant viral associations with specific cell types and tissue conditions.

The paper identifies a new rostral midline progenitor population in human embryos using spatial transcriptomics and shows their role in mesoendoderm induction.

This study uses wearable EEG and eye tracking to show that pupil-brain coupling has frequency-dependent organization and EEG-to-pupil directional coupling, comparable to stationary equipment.

The paper compares larval single-cell transcriptomes of sponges and cnidarians to explore the evolutionary origins of neural and sensory cell types.

The paper uses subcellular spatial transcriptomics to identify why some neurons in Alzheimer's disease accumulate tau while others resist it, finding differences in molecular programs and neuron-glia interactions.

This study shows that therapeutic anti-IgE antibodies form immune complexes with distinct functional properties, influenced by allergen incorporation and receptor binding patterns.

This study demonstrates the transferability of homoserine lactone sensors between Bacillales bacteria, enabling programmable interphyla communication between Gram-negative and Gram-positive species.

The paper identifies a CHRM1-IL-17 neuroimmune axis that promotes diabetic wound healing through cholinergic modulation and local AChE inhibition.

This study shows mutant IDH1 increases sEV secretion and alters their cargo composition in glioma and chondrosarcoma cells, with D2HG packaged into sEVs and cell-type-specific cargo remodeling.

The paper identifies subgroup-specific isoform usage and switching in SLE patients with distinct autoantibody profiles, highlighting their functional relevance in autoimmune pathogenesis.

The paper evaluates temporal complexity measures in resting-state fMRI to identify disease-related changes, finding that real data show greater outliers than randomized controls.

This study uses Perturb-seq with CRISPRi to analyze how cardiac and vascular transcription factors coordinate lineage commitment and cross-lineage signaling in human cardiac organoids.

This study shows that 40 Hz visual stimulation increases gamma-band functional connectivity between visual, parietal, and frontal regions, with the visual-parietal connection being most significant.

The paper identifies clonally convergent Tfh/Tph-like CD4+ T cells that persist in the mucosa after recovery from periodontitis and contribute to recurrence.