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This study uses AAV2/9 gene transfer to modify tear film composition in mice, showing long-term secretion of nerve growth factor to support corneal health.

The paper identifies trans-syncytial nanopores in the placental syncytiotrophoblast as pathways for paracellular diffusion, supported by 3D visualization and mathematical modeling.

This study shows that intestinal inflammation worsens Parkinson's disease symptoms in male mice with the LRRK2 G2019S mutation, but not females, through sex-dependent mechanisms involving α-synuclein accumulation.

The paper reanalyzes 25 studies supporting the Thermal Tolerance Trade-off Hypothesis, finding most results are spurious due to regression to the mean.

This study uses in vivo temporal labeling to show age-dependent changes in mouse platelet function and mRNA conservation.

This study shows male mice have worse joint damage and persistent synovial inflammation after ACLR injury compared to females.

This study uses multiplex epigenome editing to reactivate MECP2 from the inactive X chromosome in RTT neurons, rescuing neuronal defects in vitro.

This study shows that intermittent elamipretide injections in aged mice preserve exercise tolerance and skeletal muscle function but not heart or kidney function, unlike continuous treatment.

This study identifies miR-29 as a key driver of aging-related phenotypes by showing its upregulation in aging models and its ability to induce aging traits when overexpressed.

This study evaluates how age, sex, and biopsy methods affect mitochondrial respiration in mouse muscle fibers and introduces a protocol to reduce variability.

This study shows that late exercise training in mice reduces atherosclerosis and alters gut microbiota composition, while early exercise does not produce similar benefits.

This study shows environmental microbes cause significant phenotypic variation in Drosophila reproduction and sleep behavior, which is reversed by removing the microbes.

This study uses optically pumped magnetometers to measure the intestinal magnetic field of a rabbit, showing their potential for noninvasive disease detection.

This study evaluates commercially available glucagon receptor antibodies and identifies a specific antibody for GCGR localization, confirming liver and kidney as primary glucagon targets.

The paper identifies a plasma globulin in poison frogs that binds and regulates alkaloid bioavailability, revealing a novel serpin-based mechanism for small molecule transport.

This study shows that MMP2 loss causes dystocia and uterine fibrosis in mice, highlighting its role in parturition.

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

This study shows that BRAF in cardiomyocytes is essential for male mouse cardiac hypertrophy and fibrosis in hypertension but has opposing effects in physiological hypertrophy, with sex-specific differences.

This study shows that canagliflozin treatment in C57BL6 male mice reduces weight gain and increases median survival.

This study shows that Maresin 1 treatment reduces fibrosis and improves muscle regeneration after volumetric muscle loss by modulating inflammation.