B. Kim

This study develops KP-VR2, a novel VEGF-Trap that neutralizes VEGF-A, VEGF-B, and PlGF, showing improved antitumor efficacy compared to existing therapies.

The paper establishes quantitative rules for the locations, amounts, and variation of 25 cellular structures in human iPSCs using high-resolution imaging and analysis.

The paper identifies two genetically distinct subpopulations in swordtail fish hybrid zones, suggesting strong assortative mating and limited gene flow.

This paper introduces an image analysis script to quantify nuclear dry mass using fluorescent and quantitative phase images, revealing a correlation between nuclear dry mass and filopodia dynamics in cervical epithelial cells.

This study compares 80 kVp and 80/Sn150 kVp CT in oncology patients, finding 80 kVp provides better image quality and lower radiation dose.

This study identifies LXRalpha as a driver of chemoresistance in TNBC through its regulation of P-glycoprotein, linking cholesterol metabolism to chemotherapy failure.

This paper introduces a method using Nanotrap(R) particles to improve SARS-CoV-2 detection in pooled samples, saliva, and transport medium by concentrating virus before RNA extraction.

This paper develops a multiplex CRISPRi platform in Legionella pneumophila to silence up to ten virulence genes simultaneously, demonstrating its effectiveness in both axenic growth and macrophage infection.

This study shows that SUMOylation of SAMHD1 at K595 is necessary for its antiviral activity in non-cycling cells, independent of its dNTPase function.

The paper introduces VIR-CLASP, a method to identify RNA virus-host protein interactions by cross-linking and solid-phase purification, and demonstrates its application with 4SU-labeled viral genomes.

This study shows that RU.521 inhibits human and mouse cGAS, reducing cGAMP production and cytokine expression in response to dsDNA, without affecting RNA or interferon-induced responses.

The paper uses machine learning to link drug targets with adverse drug reactions using in vitro pharmacology data and FDA reports, identifying 221 target-ADR associations.

This study shows that thymidylate synthase promotes de-differentiation in aggressive breast cancers by supporting pyrimidine catabolism and EMT, correlating with poor prognosis.

This study shows dihydropyrimidines are cytotoxic metabolites that cause DNA replication stress and DPCs, suggesting DHP inhibition could target solid tumors.

This study shows that the CBFβ-MYH11 fusion protein inhibits megakaryocyte differentiation by disrupting the GATA2 and KLF1 gene program in inv(16) AML cells.

This study shows that AhR and IFN-gamma activation repress CDK1/2 and cyclins, reducing dNTP levels and inhibiting HIV-1 and HSV-1 replication.

The paper uses genomic profiling of tumor spheroids from malignant ascites to evaluate tumor evolution in an ovarian cancer patient, finding genetic differences between primary tumor and spheroids.