B. Schwarz

The small iron-deficiency-induced protein OLIVIA and its relation to the bHLH transcription factor POPEYE

This study identifies OLIVIA as a small Fe deficiency-induced protein that interacts with the bHLH transcription factor POPEYE, influencing Fe homeostasis and leaf growth.

Diet-induced changes in metabolism influence immune response and viral shedding dynamics in Jamaican fruit bats

The study shows diet affects viral shedding in Jamaican fruit bats, with suboptimal-sugar diets leading to higher viral RNA shedding than suboptimal-fat diets.

The intracellular growth of the vacuolar pathogen Legionella pneumophila is dependent on the acyl chain composition of host membranes

This study shows that Legionella pneumophila replication depends on host membrane acyl chain composition, with palmitoleic acid promoting membrane disorder and enhancing bacterial growth.

Lipin-1 restrains macrophage lipid synthesis to promote inflammation resolution.

This study shows that lipin-1 limits macrophage lipid synthesis, which supports inflammation resolution by enhancing efferocytosis.

Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques

The combination of molnupiravir and nirmatrelvir inhibits SARS-CoV-2 replication and shedding more effectively than individual treatments in the rhesus macaque model.

Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection

This study shows that eosinophils migrate to the lungs early after Mycobacterium tuberculosis infection in mice and macaques, mediated by GPR183 and Ch25h, independent of CCR3.

The effector FEP3/IRON MAN1 modulates interaction between BRUTUS-LIKE1 and bHLH subgroup IVb and IVc proteins

A targeted yeast two-hybrid screen identified interactions between E3 ligases BTSL1/BTSL2, bHLH subgroup IVb/IVc transcription factors, and effector FEP3/IMA1, revealing FEP3/IMA1 inhibits BTSL1-mediated degradation of bHLH proteins during Fe deficiency.

Age-related differences in immune dynamics during SARS-CoV-2 infection in rhesus macaques

This study compares immune dynamics in young and old rhesus macaques infected with SARS-CoV-2, finding age-related differences in post-acute immune responses but similar acute disease outcomes.

Western diet increases COVID-19 disease severity in the Syrian hamster

This study shows that a Western diet worsens COVID-19 outcomes in Syrian hamsters by increasing weight loss, lung damage, and systemic inflammation.

Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2

This study shows hydroxychloroquine does not reduce SARS-CoV-2 replication or improve clinical outcomes in hamsters or macaques.

Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2

This study shows remdesivir reduces SARS-CoV-2 viral load and lung damage in rhesus macaques when administered early in infection.

Putative cis-regulatory elements predict iron deficiency responses in Arabidopsis roots

The paper identifies 100 putative cis-regulatory elements that predict Arabidopsis root responses to iron deficiency using computational analysis of genome and transcriptome data.

Global distribution of earthworm diversity

The paper predicts global patterns of earthworm diversity, abundance, and biomass using a dataset from 7000 sites, finding climate drives these patterns but with differences from aboveground taxa.