K. Bi

The up-regulation of TGF-beta1 by miRNA-132-3p/WT1 is involved in inducing leukemia cells to differentiate into macrophages

This study shows that miRNA-132-3p/WT1/TGF-beta1 axis regulates the differentiation of THP-1 leukemia cells into macrophages.

Genetic basis of aposematic coloration in a mimetic radiation of poison frogs

This study identifies genes underlying Mullerian mimicry in poison frogs and shows that mimicry evolved through independent selective sweeps on color and pattern loci.

Spatially aware deep learning reveals tumor heterogeneity patterns that encode distinct kidney cancer states

The paper uses spatially aware deep learning to identify tumor heterogeneity patterns in kidney cancer, revealing distinct states associated with different histological subtypes.

Dalpiciclib Partially Abrogates ER Signaling Activation Induced by Pyrotinib In HER2+HR+ Breast Cancer

The paper investigates how dalpiciclib affects ER signaling activation induced by pyrotinib in HER2+HR+ breast cancer and identifies CALML5 as a risk factor.

Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors

This study analyzes single-cell transcriptomes of gastroenteropancreatic neuroendocrine tumors to identify lineage diversity and immunosuppressive programs in tumor and immune cells.

Dalpiciclib and Pyrotinib Exert Synergistic Antitumor Effects in Triple Positive Breast Cancer

This study shows that combining dalpiciclib with pyrotinib is more effective than pyrotinib with tamoxifen in treating triple-positive breast cancer, with CALML5 as a potential biomarker.

Botrytis cinerea BcPTP1 is a late infection phase, cysteine rich protein cytotoxic effector

This study identifies BcPTP1 as a phytotoxic effector secreted by Botrytis cinerea during late infection, which induces cell death and promotes lesion spreading.

The Botrytis cinerea Crh transglycosylae is a cytoplasmic effector triggering plant cell death and defense response

This study identifies BcCrh1 as a cytoplasmic effector of Botrytis cinerea that induces plant cell death and defense responses during infection.

A holobiont view of island biogeography: unraveling patterns driving the nascent diversification of a Hawaiian spider and its microbial associates

This study examines the evolutionary patterns of a Hawaiian spider and its microbial associates across volcanic islands, finding distinct diversification trends among host spiders, endosymbionts, and gut microbiota.

Integrative Molecular Characterization of Sarcomatoid and Rhabdoid Renal Cell Carcinoma Reveals Determinants of Poor Prognosis and Response to Immune Checkpoint Inhibitors

This study characterizes the molecular features and immune profile of sarcomatoid and rhabdoid renal cell carcinoma, showing their responsiveness to immune checkpoint inhibitors and identifying key genetic and transcriptional determinants.