M. Deng

Distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance and resetting in winter wheat

This study identifies distinct roles of H3K27me3 and H3K36me3 in vernalization response, maintenance, and resetting in winter wheat by analyzing transcriptome and chromatin dynamics.

Cultivation of host-adapted Cryptosporidium parvum and Cryptosporidium hominis using enteroids for cryopreservation of isolates and transcriptomic studies of infection

This paper develops a method to cultivate and cryopreserve Cryptosporidium hominis and C. parvum using enteroids, showing improved transcriptomic responses compared to conventional cell systems.

Carcinogenesis is associated with sex-biased tissue environments and imbalances between estrogen receptor alpha and thyroid hormone receptors

This study identifies sex-biased tissue environments and hormonal receptor imbalances as factors influencing cancer incidence patterns and carcinogenesis direction.

Preclinical Basis of the Efficacy and Pharmacodynamics of Finotonlimab, a Humanized Anti-PD-1 Monoclonal Antibody with Potent Implications for Clinical Benefit

This paper evaluates the preclinical efficacy and pharmacodynamics of Finotonlimab, a humanized anti-PD-1 antibody, showing high PD-1 binding affinity and sustained receptor occupancy in cynomolgus monkeys.

EFNB1 level affects drug response in DLBCL cell lines

This study shows that EFNB1 levels influence drug response in DLBCL cell lines by affecting phosphorylation networks and sensitivity to targeted and cytotoxic drugs.

Establishment of primary renal lymphoma model and the clinical relevance

The paper establishes a novel MA-K cell line that models primary renal lymphoma and identifies biomarkers predictive of clinical outcomes in DLBCL.

Phylogenomics reveals the relationships of butterflies and moths (Lepidoptera): providing the potential landscape using universal single copy orthologues

This study improves the phylogenetic understanding of Lepidoptera by increasing taxon sampling and analyzing the impact of sampling and long-branch attraction on tree topology.

Fat Extract Modulates Calcium Signaling and Protects Against Hyperactive Osteoclastogenesis in Bone Remodeling with Antioxidant Capacity

This study investigates the effects of cell-free fat extract (CEFFE) on osteoclastogenesis, showing its ability to reduce bone loss and inhibit osteoclast formation through antioxidant and calcium signaling modulation.

Coevolution-based prediction of key allosteric residues for protein function regulation

This paper introduces KeyAlloSite, a method to predict key allosteric residues using coevolutionary coupling, showing its accuracy in known proteins and applications in drug design and enzyme engineering.

Testis-specific H2BFWT disrupts nucleosome integrity through reductions of DNA-histone interactions

This study identifies H2BFWT's role in spermatogenesis by showing its impact on nucleosome stability and gene expression through structural and functional analyses.

Portrait of a genus: the genetic diversity of Zea

This study maps genetic diversity across Zea species, identifying millions of variants and adaptive genes, and demonstrates their utility in breeding.

BacAnt: A Combination Annotation Server for Bacterial DNA Sequences to Identify Antibiotic Resistance Genes, Integrons, and Transposable Elements.

BacAnt is a webserver that simultaneously annotates antibiotic resistance genes, integrons, and transposable elements in bacterial DNA sequences, generating automated genbank files.

Rapidly cycling stem cells regenerate the intestine independent of Lgr5high cells

This study identifies Msi1+ cells as rapidly cycling intestinal stem cells that regenerate the intestine independently of Lgr5high cells.

Stromal ISLR promotes intestinal regeneration and cancer by suppressing epithelial Hippo signaling

This study identifies ISLR as a stromal factor that suppresses epithelial Hippo signaling to promote intestinal regeneration and cancer.

Genomic landscape of the global oak phylogeny

This study investigates oak genome diversity and phylogeny using RAD-seq data, finding that oak diversity is shaped by gene flow and genomic mosaicism.

A Framework to Incorporate D-trace Loss into Compositional Data Analysis

The paper proposes a framework integrating D-trace loss with compositional data analysis to improve network and differential network inference from microbial data.

Liver physiological T1rho dynamics associated with age and gender

The paper measures liver T1rho relaxation times in women and men across different ages and menstrual phases, finding age-dependent decreases in women but not men, and no BMI association.

A Combined Use Of Intravoxel Incoherent Motion MRI Parameters Can Differentiate Early Stage Hepatitis-B Fibrotic Livers From Healthy Livers

This study uses IVIM parameters to differentiate early-stage hepatitis-B fibrotic livers from healthy livers with high accuracy.