SARS-CoV-2 and SARS-CoV Spike-RBD Structure and Receptor Binding Comparison and Potential Implications on Neutralizing Antibody and Vaccine Development
This study compares SARS-CoV-2 and SARS-CoV spike-RBD binding to ACE2, showing similar affinities but differing neutralizing antibody cross-reactivity, highlighting challenges for broad-spectrum vaccines.