Author

D. Bezwada

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:metabolomics· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Approach:genetic perturbation / CRISPR· 1 Approach:statistical model· 1

Frequent Co-Authors

R. J. DeBerardinis· 5 shared B. Brooks· 3 shared F. Cai· 3 shared H. S. Vu· 3 shared L. Cai· 3 shared A. B. Aurora· 2 shared A. Leach· 2 shared D. Do· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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5 shared papersCancer Biology

R. J. DeBerardinis

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Glycosaminoglycan-mediated lipoprotein uptake protects cancer cells from ferroptosis

D. Calhoon, L. Sang, D. Bezwada, N. Kim, A. Basu, S.-C. Hsu, A. Pimentel, B. Brooks, K. La, A. Paulina Serrano, D. L. Cassidy, L. Cai, V. Toffessi-Tcheuyap, V. Margulis, F. Cai, , J. Garcia-Bermudez

This study identifies glycosaminoglycan-mediated lipoprotein uptake as a mechanism by which cancer cells resist ferroptosis and lipid oxidative stress.

bioRxiv · May 13, 2024Cancer Biology

Electron transport inhibition increases cellular dependence on purine transport and salvage

Z. Wu, D. Bezwada, R. C. Harris, C. Pan, P. T. Nguyen, B. Faubert, L. Cai, F. Cai, H. S. Vu, H. Chen, M. Martin-Sandoval, D. Do, W. Gu, Y. Zhang, B. Ko, , R. J. DeBerardinis

This study shows that ETC inhibition in cancer cells increases reliance on purine salvage and transport, revealing a metabolic vulnerability in tumors with low oxidative metabolism.

bioRxiv · May 11, 2023Biochemistry

Mitochondrial metabolism in primary and metastatic human kidney cancers

D. Bezwada, R. J. DeBerardinis, N. P. Lesner, B. Brooks, H. S. Vu, Z. Wu, L. Cai, S. Kasitinon, S. Kelekar, F. Cai, A. B. Aurora, M. Patrick, A. Leach, R. Ghandour, Y. Zhang, , V. Margulis

This study investigates mitochondrial metabolism in kidney cancers, finding that primary tumors have suppressed mitochondrial function while metastases show enhanced TCA cycle labeling.

bioRxiv · Feb 6, 2023Cancer Biology

Adipocytes reprogram glucose metabolism in cancer cells promoting metastasis

A. Mukherjee, D. Bezwada, M. Zandbergen, F. Francesco Greco, C.-Y. Chiang, M. Tasdemir, J. Fahrmann, D. Grapov, M. R. La Frano, H. S. Vu, J. W. Newman, L. A. McDonnell, L. Nezi, O. Fiehn, R. J. DeBerardinis, E. Lengyel

This study shows adipocytes reprogram cancer cell glucose metabolism to promote metastasis by increasing lipid synthesis via HIF1 regulation.

bioRxiv · Oct 17, 2022 · PreprintCancer Biology

G6PD deficiency sensitizes metastasizing melanoma cells to oxidative stress and glutaminolysis

A. B. Aurora, V. Khivansara, A. Leach, J. G. Gill, M. Martin-Sandoval, C. Yang, S. Y. Kastininon, D. Bezwada, A. Tasdogan, W. Gu, T. P. Mathews, Z. Zhao, R. J. DeBerardinis, S. J. Morrison

This study shows that G6PD deficiency in melanoma cells increases oxidative stress and glutaminolysis, reducing metastasis by making cells more vulnerable to metabolic disruption.

bioRxiv · Nov 11, 2021 · PreprintCancer Biology