Mechanosensing through talin 1 contributes to tissue mechanical homeostasis
M. V. Chanduri, A. Kumar, D. Weiss, N. Emuna, I. Barsukov, M. Shi, K. Tanaka, X. Wang, A. Datye, J. Kanyo, F. Collin, T. Lam, U. D. Schwarz, S. Bai, T. Nottoli, , M. A. Schwartz
This study shows that mutations in talin1 alter cellular stiffness sensing, leading to changes in ECM mechanical properties and aortic compliance.
bioRxiv · Sep 3, 2023 · PreprintCell Biology