Protein SUMOylation promotes cAMP-independent EPAC1 activation
W. Yang, F. Mei, W. Lin, M. A. White, L. Li, Y. Li, S. Pan, X. Cheng
This study identifies SUMOylation of EPAC1 at K561 as a mechanism for cAMP-independent activation of EPAC1 through enhanced Rap1 interaction.
bioRxiv · Jan 8, 2024 · PreprintCell Biology