G. Gu

ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans

This study identifies ELO-6 expression as a predictor of longevity in isogenic C. elegans populations and shows its regulation by PQM-1.

Glucose-stimulated KIF5B-driven microtubule sliding organizes microtubule networks in pancreatic beta cells

This study shows that glucose stimulates KIF5B-mediated microtubule sliding in pancreatic beta cells, organizing microtubule networks to support insulin secretion and prevent hypoglycemia.

Protective human anti-poxvirus monoclonal antibodies are generated from rare memory B cells isolated by multicolor antigen tetramers

The paper isolates rare memory B cells from vaccinated individuals to generate anti-poxvirus monoclonal antibodies, identifying one with high efficacy against viral infection.

The microtubule minus end-binding protein CAMSAP2 does not regulate microtubule dynamics in primary pancreatic β-cells but facilitates insulin secretion

This study shows that CAMSAP2 in primary pancreatic β-cells localizes to the Golgi and supports insulin secretion by facilitating Golgi-ER trafficking, despite not regulating microtubule dynamics.

3D Printable High Performance Conducting Polymer Hydrogel for All-Hydrogel Bioelectronics

This paper develops a bi-continuous conducting polymer hydrogel with high electrical conductivity, stretchability, and fracture toughness for 3D printable bioelectronics.

Microtubules and Gαo-signaling independently regulate the preferential secretion of newly synthesized insulin granules in pancreatic islet β cells

The paper investigates how microtubules and Gαo-signaling regulate the preferential secretion of newly synthesized insulin granules in β cells, showing that their absence leads to increased secretion of older granules.

Microtubules regulate pancreatic beta cell heterogeneity via spatiotemporal control of insulin secretion hot spots

This study shows microtubules regulate beta cell heterogeneity in insulin secretion by controlling secretion hot spots through spatiotemporal dynamics.

Microtubules Regulate Spatial Localization and Availability of Insulin Granules in Pancreatic Beta Cells.

This study shows microtubules regulate insulin granule localization and PM interactions in beta cells, affecting GSIS and suggesting MT targeting as a diabetes therapy.