J. Fleming

Bioelectronic Zeitgebers: targeted neuromodulation to re-establish circadian rhythms.

This paper introduces a bioelectronic system for circadian neuromodulation that adjusts therapy based on the sleep/wake cycle, showing effectiveness in two patient phenotypes.

Deep learning in human neurons predicts mechanistic subtypes of Parkinson's

This study uses deep learning on patient-derived neurons to predict Parkinson's disease subtypes with high accuracy, highlighting mitochondrial and lysosomal features as key predictors.

Convergent evolution of polyploid genomes from across the eukaryotic tree of life

This study models gene loss in polyploid genomes across eukaryotes, showing convergent evolutionary patterns and reciprocal gene loss barriers.

Utilizing Pine Needles to Temporally and Spatially Profile Per- and Polyfluoroalkyl Substances

This study uses pine needles and a non-targeted method to detect over 70 PFAS across six decades, revealing temporal and spatial patterns of exposure and contamination.

Cyclocreatine suppresses prostate tumorigenesis through dual effects on SAM and creatine metabolism

This study identifies cyclocreatine as a dual-action inhibitor of prostate cancer by blocking the phosphagen system and increasing S-adenosyl methionine levels.

Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition

This study shows that combining glucose metabolism inhibition with MEK inhibition enhances apoptosis in pancreatic cancer cells by inducing ER stress.