Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates
E. J. Fay, K. Isterabadi, C. M. Rezanka, J. Le, M. D. Daugherty
The paper analyzes the evolutionary and functional roles of RIPK3 and its RHIM domain across vertebrates, finding that RHIM diversity tunes NF-κB activation while preserving cell death function.
bioRxiv · May 9, 2024Evolutionary Biology