K. Sato

This study determines the cryo-EM structure of NSD2 bound to a nucleosome and identifies oncogenic mutations that increase its catalytic activity by altering the autoinhibitory loop conformation.

This study identifies two amino acid sites in whale shark rhodopsin that contribute to its blue shift and thermal stability, enabling its wide vertical range.

This study shows that Mu variant is highly resistant to neutralization by convalescent and vaccine sera compared to other variants.

The paper investigates the SARS-CoV-2 Lambda variant, finding it more infectious due to specific mutations and better immune evasion, contributing to its spread in South America.

This study shows the P681R mutation in the SARS-CoV-2 spike protein enhances fusogenicity and pathogenicity in the Delta variant compared to the prototypic virus.

This study compares gene expression responses in Solanum torvum infected with two Meloidogyne arenaria pathotypes, identifying distinct molecular mechanisms of resistance and susceptibility.

This study identifies two SARS-CoV-2 mutations, L452R and Y453F, that evade HLA-restricted cellular immunity and increase viral infectivity.

The paper introduces POLArIS, a probe for molecular orientation imaging, and demonstrates its use in visualizing actin filaments associated with microtubule asters in early embryos.

This paper uses spatial single-cell omics to analyze PDAC tumors and microenvironment, identifying key populations and interactions that may inform treatment strategies.

This study shows that the mevalonate pathway regulates ER homeostasis, which is essential for maintaining haploid stability in human somatic cells.

This study identifies two factors determining phototactic sign reversal in Chlamydomonas reinhardtii through high-speed observation and a mathematical model.

The paper shows wild-type sTREM2 inhibits Aβ aggregation and neurotoxicity, while the R47H variant promotes Aβ aggregation and neurotoxicity.

The paper identifies a three-step mechanism for resolving G-quadruplex structures during DNA replication using Xenopus egg extracts.

The paper quantifies the flight performance and wind requirements of extinct giant birds and pterosaurs, finding conflicting results with previous studies on their soaring styles.

This paper introduces an autocorrelation-based method to assess rhythmic irregularity in Parkinson's disease tasks, showing comparable performance to existing approaches.

This study shows that IFITM proteins are required for SARS-CoV-2 infection and can be targeted to inhibit viral entry and replication.

The paper shows that a drastic shift in flowering phenology in hybrids of Imperata cylindrica prevents backcrossing, leading to a population structure dominated by F1 hybrids.

This study shows that high RAD51 expression in ovarian cancer is linked to poor survival and platinum resistance, particularly in HRD-negative tumors, and correlates with immune exclusion.

This study evaluates a new SARS-CoV-2 detection kit that skips RNA extraction and purification, showing high concordance with direct PCR across multiple sample types.

This paper shows that SARS-CoV-2 ORF3b is a potent interferon antagonist, with a naturally occurring longer variant enhancing its anti-interferon activity in severe COVID-19 cases.

The paper tracks EBV infection in B-cells using fate mapping and RNA-seq, showing abortive lytic infection precedes latency.

The paper shows HERV activation in tumors upregulates KZFPs, which suppress cancer progression by downregulating cell cycle and adhesion genes, improving disease outcomes.

This study investigates the evolutionary conflict between APOBEC3 genes and ancient retroviruses, finding that APOBEC3 gene amplification and positive selection correlate with retroviral G-to-A mutation signatures.