L. Yu

This study investigates the molecular mechanism of PA transfer by Ups1/Mdm35 using crystal structures, molecular dynamics simulations, and biophysical assays, revealing conformational changes and regulatory factors.

The paper shows Cyclin B1-CDK1 binds MAD1 at the nuclear pore, coordinating NPC disassembly with kinetochore assembly to maintain chromosomal stability.

The paper characterizes the midbody interactome, revealing PP1 phosphatases regulate microtubule dynamics and centralspindlin complex function during cytokinesis.

This study tracks the development of a potent ZIKV-specific antibody in a convalescent human, revealing limited somatic hypermutation and high germline identity.

This study investigates transcriptomic responses of Symbiodinium kawagutii to thermal stress, phosphate deprivation, and glycerol-3-phosphate replacement, identifying core genes and differentially expressed genes across conditions.

This paper introduces E2~dID, a method to identify substrates modified by ubiquitin and ubiquitin-like molecules using E2-thioester conjugates, validated in human and yeast systems.

This paper introduces a tumor-specific causal inference framework to identify causative somatic genome alterations and their impact on molecular phenotypes in individual tumors.

The paper creates a multi-omic atlas of the human frontal cortex using data from aging and Alzheimer's studies, providing insights into brain biology and disease mechanisms.

This study identifies phosphoregulation networks during Plasmodium gamete formation using high-resolution phosphoproteomics.