T. Sharma

A biodegradable microgrooved and tissue mechanocompatible citrate-based scaffold improves bladder tissue regeneration

This paper develops a biodegradable scaffold that enhances bladder tissue regeneration in rats by incorporating microgrooves and stem cells, improving bladder function and structure.

Androgens at the skin surface regulate S. aureus pathogenesis through the activation of agr quorum sensing

This study shows that androgens like testosterone promote S. aureus pathogenesis by activating the agr quorum sensing system, leading to increased virulence and skin infection.

Minor changes in electrostatics robustly increase VP40 membrane binding, assembly, and budding of Ebola virus matrix protein derived virus-like particles

This study shows that minor electrostatic changes in VP40 significantly affect membrane binding, assembly, and budding of Ebola virus-like particles.

Fusarium graminearum Ste2 and Ste3 Receptors Undergo Peroxidase Induced Heterodimerization

This study shows that FgSte2 and FgSte3 GPCRs in F. graminearum form heterodimers in response to peroxidase and HRP-derived ligands, using bioluminescence resonance energy transfer and affinity pulldown.

Proteomic profiling of regenerated urinary bladder tissue with stem cell seeded scaffold composites in a non-human primate bladder augmentation model

This study compares protein expression in bladder tissue regenerated with stem cell-seeded scaffolds to native tissue and BAE tissue in baboons, finding higher homogeneity in scaffold-regenerated tissue.

VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection

This study shows that the VapC12 toxin in Mycobacterium tuberculosis modulates host immune responses, promoting pathogen survival by altering T-cell and neutrophil responses.

Hypothetical gene Rv0495c regulates redox homeostasis in Mycobacterium tuberculosis

This study identifies Rv0495c as a regulator of redox homeostasis in Mtb, showing that its absence increases ROS and susceptibility to stress, yet enhances pathogenicity in host models.

Deferoxamine as adjunct therapeutics for tuberculosis

This study shows Deferoxamine (DFO) has antimycobacterial properties and can reduce Mtb burden when used as an adjunct to standard tuberculosis treatments.

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

The paper identifies adaptive pathways in metabolic liver disease by selecting somatically mutated clones in mice and humans, finding mutations that ameliorate lipotoxicity and promote clonal expansion.

Significance of the RBD mutations in the SARS-CoV-2 Omicron: from spike opening to antibody escape and cell attachment

This study computationally examines how Omicron's RBD mutations affect its structure, ACE2 binding, and antibody evasion, suggesting enhanced infectivity and immune escape.

Anisotropic interaction and motion states of locusts in a hopper band

This study analyzes the movement patterns of locusts in hopper bands, identifying three motion states and anisotropic interactions based on relative neighbor positions.

A kiwellin protein-like fold containing rust effector protein localizes to chloroplast and suppress cell death in plants

This study identifies kiwellin-like proteins in rust fungi as potential effectors that suppress plant cell death by localizing to chloroplasts.

Horizontal transfer of a conserved npc-2 like effector gene in rust fungi that suppresses cell death in plants

The paper identifies a horizontally transferred NPC2-like effector gene from rust fungi that suppresses plant cell death by lipid binding, showing functional conservation with animal NPC2 proteins.