Author

S. Heissel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:metabolomics· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

E. R. Gamazon· 2 shared H. Alwaseem· 2 shared H. Molina· 2 shared K. Birsoy· 2 shared A. Jankevics· 1 shared A. Khan· 1 shared A. Pinzaru· 1 shared B. Allwein· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

E. R. Gamazon

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Fast and accurate disulfide bridge detection

S. Heissel, Y. He, A. Jankevics, Y. Shi, H. Molina, R. Viner, R. A. Scheltema

This paper presents a fast and accurate method for detecting disulfide bridges in proteins using mass spectrometry with optimized sample preparation and data analysis.

bioRxiv · Nov 22, 2023Biochemistry

The resting and ligand-bound states of the membrane-embedded human T-cell receptor-CD3 complex

R. Q. Notti, F. Yi, S. Heissel, M. W. Bush, Z. Molvi, P. Das, H. Molina, C. A. Klebanoff, T. Walz

This study presents cryo-EM structures of the human TCR-CD3 complex in its resting and ligand-bound states, revealing conformational changes and the importance of native lipid environments.

bioRxiv · Aug 22, 2023Biochemistry

Arginine limitation causes a directed DNA sequence evolution response in colorectal cancer cells

D. Hsu, J. Gao, N. Yamaguchi, A. Pinzaru, N. Mandayam, M. Liberti, S. Heissel, H. Alwaseem, S. Tavazoie, S. Tavazoie

This study shows that arginine limitation in colorectal cancer cells drives DNA sequence evolution away from arginine codons, leading to altered proteins.

bioRxiv · Jan 2, 2023 · PreprintCancer Biology

Integrative genetic analysis identifies FLVCR1 as an essential component of choline transport in mammals

T. C. Kenny, A. Khan, Y. Son, L. Yue, S. Heissel, E. R. Gamazon, H. Alwaseem, R. K. Hite, K. Birsoy

The paper identifies FLVCR1 as essential for choline transport in mammals through integrative genetic analysis and functional studies.

bioRxiv · Oct 5, 2022Cell Biology

SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells

Y. Wang, F. S. Yen, X. G. Zhu, R. C. Timson, R. Weber, C. Xing, Y. Liu, B. Allwein, H. Luo, H.-W. Yeh, S. Heissel, G. Unlu, E. R. Gamazon, M. G. Kharas, R. Hite, K. Birsoy

This study identifies SLC25A39 as a mitochondrial glutathione importer and shows its role in cell proliferation and red blood cell development, with GSH availability regulating its abundance.

bioRxiv · Sep 15, 2021Biochemistry