M. Ren

Promiscuous NAD-dependent dehydrogenases enable efficient bacterial growth on the PET monomer ethylene glycol

This study identifies NAD-dependent dehydrogenases in Paracoccus denitrificans that enable efficient bacterial growth on ethylene glycol, with implications for biotechnological applications.

Targeting the WSB2-NOXA Axis in Cancer Cells for Enhanced Sensitivity to BCL-2 Family Protein Inhibitors

This study identifies WSB2 as a regulator of mitochondrial apoptosis and shows that targeting the WSB2-NOXA axis enhances sensitivity to BCL-2 inhibitors in cancer cells.

Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction and leads to increased glucose uptake in tafazzin-deficient cells

This study identifies the upregulation of the AMPK-FOXO1-PDK4 pathway as the mechanism causing reduced PDH activity and increased glucose uptake in tafazzin-deficient cells.

Chromosome-scale Genome Assembly of the Allopolyploid Arundo donax

This study presents two chromosome-scale genome assemblies of the allopolyploid plant Arundo donax, revealing its polyploid nature and evolutionary history through gene family expansion and whole-genome duplication events.

Distinct super-enhancer elements differentially control Il2ra gene expression in a cell-type specific fashion

The paper identifies distinct super-enhancer elements that differentially regulate Il2ra expression in DN2/DN3 thymocytes and Treg cells versus mature T and NK cells.

A Mechanistic Study on the Cellular Uptake, Intracellular Trafficking, and Antisense Gene Regulation of Bottlebrush Polymer-Conjugated Oligonucleotides

This paper investigates the cellular uptake, trafficking, and antisense gene regulation mechanisms of bottlebrush polymer-conjugated oligonucleotides in cancer cells.

The Biogeography of Fungal Communities Across Different Chinese Wine-producing Regions Associated with Environmental Factors and Spontaneous Fermentation Performance

This study analyzes fungal communities in Chinese Marselan wine fermentation across regions, finding that environmental factors significantly influence fungal composition and fermentation performance.