J. Newman

Global variation in prior exposure shapes antibody neutralization profiles of SARS-CoV-2 variants up to BA.2.86

The paper analyzes antibody neutralization data from multiple countries to assess how prior exposure to SARS-CoV-2 variants affects neutralization profiles of BA.2.86 and its descendants.

Vgamma9Vdelta2 T cells recognize butyrophilin 2A1 and 3A1 heteromers

The paper reveals that Vgamma9Vdelta2 T cells recognize BTN2A1 and BTN3A1 heteromers through dual epitope engagement, uncovering a new mechanism of immune activation.

Gluebodies improve crystal reliability and diversity through transferable nanobody mutations that introduce constitutive close contacts

The paper engineers nanobody interfaces to improve crystal reliability and diversity, resulting in better diffraction and multiple polymorphs.

Distinct antigenic properties of the SARS-CoV-2 Omicron lineages BA.4 and BA.5

This study compares the antigenic properties of SARS-CoV-2 Omicron variants BA.4 and BA.5 with BA.1, BA.2, and vaccine-induced antibodies, finding they are antigenically distinct and show enhanced neutralisation breadth after breakthrough infection.

An ACAT inhibitor regulates SARS-CoV-2 replication and antiviral T cell activity

This paper shows that ACAT inhibitors like Avasimibe reduce SARS-CoV-2 replication and enhance antiviral T cell activity in patients.

Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development

This study determines the crystal structures of SARS-CoV-2 NSP14 and identifies fragment inhibitors, providing insights into its enzymatic activities and potential drug targets.

Membrane interactions and uncoating of Aichi virus, a picornavirus that lacks a VP4

This study investigates the role of VP0 in Aichi virus membrane interactions and uncoating, showing that pH affects genome exposure and pore formation analogous to VP4 in other picornaviruses.

The altered entry pathway and antigenic distance of the SARS-CoV-2 Omicron variant map to separate domains of spike protein

This study identifies distinct genetic determinants in the Omicron spike protein for altered cell entry and antigenic properties, showing they are separable and may affect future variant severity and vaccine efficacy.

SARS-CoV-2 variants of concern Alpha, Beta, Gamma and Delta have extended ACE2 receptor host-ranges

The paper examines whether SARS-CoV-2 variants Alpha, Beta, Gamma, and Delta have altered ACE2 receptor usage across different mammalian species, finding that N501Y and E484K substitutions in the Spike RBD expand their host range.

Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected Patients

This study shows that convalescent sera from SARS-CoV-2 infected patients efficiently neutralize RaTG13, a close coronavirus relative, more effectively than SARS-CoV-2 itself.

The ChAdOx1 vectored vaccine, AZD2816, induces strong immunogenicity against SARS-CoV-2 Beta (B.1.351) and other variants of concern in preclinical studies.

Diet High in Soybean Oil Increases Susceptibility to Colitis in Mice

This study shows that a soybean oil-rich diet increases colitis susceptibility in mice by altering HNF4, gut microbiota, and metabolites.

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

This study develops a vaccine candidate using SpyCatcher technology to display the SARS-CoV-2 RBD, showing strong neutralizing antibody responses in mice and pigs.

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

This study evaluates the immunogenicity of single and booster doses of the ChAdOx1 nCoV-19 vaccine in mice and pigs, finding that a booster significantly enhances antibody responses, especially in pigs.

Mechanism and inhibition of SARS-CoV-2 PLpro

This study investigates SARS-CoV-2 PLpro's mechanism and identifies non-covalent inhibitors with antiviral activity.

The Low-Cost, Semi-Automated Shifter Microscope Stage Transforms Speed and Robustness of Manual Protein Crystal Harvesting

The Shifter microscope stage automates parts of protein crystal harvesting, increasing mounting rates and reducing manual effort while maintaining diffraction quality.

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages

This study identifies CD38+ macrophages as a driver of NAD decline during aging through inflammation linked to cellular senescence in metabolic tissues.