GGCX promotes Eurasian avian-like H1N1 swine influenza virus adaption to interspecies receptor binding
J. Zou, M. Jiang, R. Xiao, H. Sun, H. Liu, T. Peacock, S. Tu, T. Chen, J. Guo, Y. Zhao, W. Barclay, S. Xie, H. Zhou
This study identifies GGCX as a key factor enabling EA H1N1 SIV adaptation to human-type -2,6 sialic acid receptors through HA carboxylation, suggesting it as a potential antiviral target.
bioRxiv · Mar 18, 2024Microbiology