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This study shows JAG1-NOTCH4 signaling promotes atherosclerosis by repressing endothelial repair in response to low oscillatory shear stress.

The paper examines ACE2, TMPRSS2, and Furin expression in nasal and olfactory tissues of humans and mice to understand the mechanisms of COVID-19 related anosmia.

This paper characterizes a transmembrane TNF-driven mouse model of spondyloarthritis, showing ectopic bone formation, systemic bone loss, and comorbid heart valve pathology, with early anti-TNF treatment reducing inflammation.

This study examines ACE2 and TMPRSS2 protein expression in rat aerodigestive tracts to understand SARS-CoV-2 infection mechanisms and correlate with COVID-19 symptoms.

This study uses single-cell RNA-seq to analyze keloid tissue and identifies lineage-specific regulatory changes in fibroblasts and vascular endothelial cells, highlighting key pathways and potential therapeutic targets.

This study evaluates how ischemic preconditioning (IPC) affects myocardial damage caused by mCRP deposition in a rat model of ischemia-reperfusion injury, finding reduced infarct size and mCRP deposition with IPC.

This paper uses a systems-thinking model to simulate energy dynamics in virus-host interactions, identifying virion assembly as a key target for limiting virus spread.

This paper introduces a rapid, point-of-care red blood cell agglutination assay for detecting SARS-CoV-2 antibodies using a fusion protein that binds RBCs and displays the SARS-CoV-2 RBD.

The paper assesses disease responses in hexaploid spring wheat culms with premature senescence caused by Fusarium pseudograminearum, finding greater disease severity in senescent culms.

This study shows that gut dysbiosis reduces liver injury in autophagy-deficient mice through FXR-FGF15 signaling, suggesting caution in antibiotic use during liver disease.

The paper shows that pericytes, not endothelial cells, express ACE2 in microvessels, suggesting they may be infected in COVID-19 and contribute to microvascular inflammation and hypercoagulopathy.

This study shows ACE2 and TMPRSS2 are expressed on human ocular surface cells, suggesting they can be infected by SARS-CoV-2.

This study shows that inhibiting E2F4 in Alzheimer's mice reduces inflammation, Aβ proteostasis issues, and cognitive decline, suggesting E2F4 as a therapeutic target.

This paper develops an inducible mouse model of childhood HIV-associated nephropathy (HIVAN) and shows HIV-Tat contributes to the disease when combined with other HIV-1 genes and heparin-binding cytokines.

This study investigates recent trends and risk factors of sleep-related sudden infant deaths in Japan, identifying high odds ratios for teenage mothers and later birth order.

FalseColor-Python converts grayscale fluorescence images to H&E-like color images, offering automated, uniform false coloring and GPU acceleration for 2D/3D microscopy datasets.

This study identifies redox and protein homeostasis as key factors in toxin-induced biliary atresia, showing that genetic modulation of these pathways affects cholangiocyte injury and suggesting potential therapeutic strategies.

The paper examines WT1 expression in endometrium across different physiological and pathological conditions, linking it to progesterone effects and gestational vascular changes.

This paper uses a mouse model of spinal muscular atrophy to study non-alcoholic fatty liver disease, finding that it develops steatohepatitis and identifies molecular mechanisms involved.

This study shows that heme-induced ER stress in leukocytes of HIV-positive individuals with chronic widespread pain reduces β-endorphin levels, contributing to increased pain sensitivity.