Author

P. Shen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Evolutionary Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 3 Organism:bacteria (other)· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:DNA methylation· 1

Frequent Co-Authors

J. Liu· 2 shared A. C. Kruse· 1 shared A. Xu· 1 shared C. Gao· 1 shared C. J. Logothetis· 1 shared C. McMahon· 1 shared C. Tian· 1 shared C. Xu· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersMicrobiology

J. Liu

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Antibodies Expand the Scope of Angiotensin Receptor Pharmacology

M. A. Skiba, S. M. Sterling, S. Rawson, M. S. A. Gilman, H. Xu, G. R. Nemeth, J. D. Hurley, P. Shen, D. P. Staus, J. Kim, C. McMahon, M. K. Lehtinen, L. M. Wingler, A. C. Kruse

This study develops nanobody antagonists against the AT1R receptor, showing they can selectively bind and modulate the receptor with tunable ligand selectivity.

bioRxiv · Aug 23, 2023Pharmacology & Toxicology

A reverse-central-dogma pathway underlies ribosome-antibiotic efficacy and accelerates resistance evolution

Y. Zheng, R. Chai, Z. Xu, Y. He, P. Shen, J. Liu, T. Wang

This study reveals a reverse-central-dogma pathway by which ribosome antibiotics cause genomic instability and accelerate resistance evolution through transcription-translation coupling disruption.

bioRxiv · Aug 3, 2023 · PreprintMicrobiology

A novel bacterial signal transduction system specifically senses and responds to peptidoglycan damage

J. Yin, C. Xu, X. Hu, T. Zhang, Y. Liang, Y. Sun, X. Zhen, Y. Zhu, Y. Luo, P. Shen, D. Cheng, Y. Sun, J. Cai, Q. Meng, T. Zhu, , Z. Yu

This study identifies a bacterial two-component system that detects and responds to peptidoglycan damage, revealing its role in antibiotic resistance and tolerance.

bioRxiv · May 5, 2023 · PreprintMicrobiology

Activation of retinoic acid receptor reduces metastatic prostate cancer bone lesions through blocking endothelial-to-osteoblast transition

G. Yu, P. G. Corn, P. Shen, J. H. Song, Y.-C. Lee, S.-C. Lin, J. Pan, S. K. Agarwal, T. Panaretakis, M. Pacifici, C. J. Logothetis, L.-y. Yu-Lee, S.-H. Lin

bioRxiv · Dec 22, 2021Cancer Biology

KRAS G12D can be targeted by potent salt-bridge forming inhibitors

Z. Mao, H. Xiao, P. Shen, Y. Yang, J. Xue, Y. Yang, Y. Shang, L. Zhang, X. Li, Y. Zhang, Y. Du, C.-C. Chen, R.-T. Guo, Y. Zhang

This study identifies potent inhibitors targeting KRAS G12D via a salt-bridge interaction, showing efficacy in reducing tumor volume and synergizing with anti-PD-1 therapy.

bioRxiv · Dec 13, 2021 · PreprintCancer Biology

Novel non-transposable-element regulation patterns of KZFP family reveal new drivers of its rapid evolution

P. Shen, Q. Zheng, A. Xu, J. Liu, Y. Hou, C. Gao, C. Tian, F. He, D. Yang

This study identifies new regulatory patterns of KZFP family zinc fingers that drive their rapid evolution by binding non-transposable element regions and positively regulating gene expression.

bioRxiv · Apr 15, 2020 · PreprintEvolutionary Biology