C. Tang

This study shows that Alk1 mutant endothelial cells expand clonally in mouse brain arteriovenous malformations (AVMs) and that BM-derived Alk1 mutant ECs can cause AVMs.

This study shows that maize heterosis for root biomass and germination depends on soil microbes, as inbred lines perform as well as F1 hybrids under sterile conditions but not when microbes are present.

The paper identifies BRAWNIN, a sORF-encoded peptide critical for vertebrate mitochondrial complex III assembly, showing its role in oxidative phosphorylation and metabolic function.

The paper analyzes mutation dynamics in a poliovirus population using high-resolution sequencing to identify interactions like clonal interference and hitchhiking that shape evolutionary trajectories.

The paper identifies a key residue in a GPCR dimer using in-cell structure characterization and shows its impact on dimerization and signaling.

This paper determines the structural basis of how Rpn13 recognizes K48-linked Ub chains through a bivalent interaction, revealing a mechanism for proteasomal selectivity.

This paper uses machine learning on whole-genome sequencing of plasma cell-free DNA to detect early-stage colorectal cancer with high sensitivity and specificity.

This study determines the first crystal structure of full-length mouse SAMHD1 in three nucleotide-bound states, revealing a more complex activation process involving the SAM domain compared to human SAMHD1.