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7 papers
Recent·Most cited
X. Lin, Z. Sha, C. Zhang, J. M. Adler, R. M. Vidal, C. Langner, B. Fu, Y. Xiong, M. Tan, C. Jiang, H. Zeng, X. Zhang, Q. Li, J. Yan, X. Lu, , Z. Zhu
This study shows that the NSP4 T492I mutation increases SARS-CoV-2 mutation rates and accelerates the emergence of Omicron-like mutations.
bioRxiv · Jul 5, 2024 · PreprintEvolutionary Biology
X. Lin, Z. Sha, J. Trimpert, D. Kunec, C. Jiang, Y. Xiong, B. Xu, Z. Zhu, W. Xue, H. Wu
The paper investigates the T492I mutation in SARS-CoV-2 NSP4, showing it increases transmissibility, replication, and antibody evasion by enhancing NSP5 cleavage efficiency and reducing viral RNA-associated chemokines.
bioRxiv · Jan 15, 2023 · PreprintMicrobiology
G. Nouailles, J. M. Adler, P. Pennitz, S. Peidli, G. Teixeira Alves, M. Baumgart, J. Bushe, A. Voss, A. Langenhagen, F. Pott, J. Kazmierski, C. Goekeri, S. Simmons, N. Xing, C. Langner, , J. Trimpert
This study compares immune responses and efficacy of different SARS-CoV-2 vaccines in hamsters, finding that a live-attenuated vaccine provides superior protection against variants.
bioRxiv · May 16, 2022Immunology
X. Lin, W. Xue, Y. Zhang, B. Fu, J. Trimpert, N. Xing, D. Kunec, W. Tang, Y. Xiao, K. Meng, S. Shi, H. Wu, G. Meng, Z. Zhu
This study shows that the nucleocapsid 203 mutation, combined with spike L452R, enhances SARS-CoV-2 immune evasion and fitness, contributing to the dominance of variants like Delta and Omicron.
bioRxiv · Dec 20, 2021 · PreprintMicrobiology
X. Lin, B. Fu, Y. Xiong, N. Xing, W. Xue, D. Guo, M. Y. Zaky, K. C. Pavani, D. Kunec, J. Trimpert, H. Wu
This study identifies unconventional secretion of unglycosylated ORF8 as critical for inducing cytokine storms during SARS-CoV-2 infection by interacting with IL17RA on macrophages.
bioRxiv · Dec 3, 2021Microbiology
N. Osterrieder, L. D. Bertzbach, K. Dietert, A. Abdelgawad, D. Vladimirova, D. Kunec, D. Hoffmann, M. Beer, A. D. Gruber, J. Trimpert
This study compares SARS-CoV-2 infection progression in young and aged Syrian hamsters, finding age-related differences in weight loss, immune response, and lung recovery.
bioRxiv · Jun 10, 2020Microbiology
S. Pach, T. N. Nguyen, J. Trimpert, D. Kunec, N. Osterrieder, G. Wolber
The paper uses molecular dynamics simulations to analyze SARS-CoV-2 ACE2 variants and predicts susceptibility in red squirrels and specific mutations in dogs, rats, and mice.
bioRxiv · May 14, 2020Pharmacology & Toxicology