Author

K. Meng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 2 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 6 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Assay:cryo-EM· 1

Frequent Co-Authors

G. Meng· 6 shared B. Fu· 2 shared H. Wu· 2 shared N. Li· 2 shared N. Xing· 2 shared W. Xue· 2 shared W. Zhu· 2 shared X. Lin· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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6 shared papersMicrobiology

G. Meng

Mutual co-authors in cluster

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10 papers

Recent·Most cited

African Swine Fever Virus major capsid p72 Trimers function as a pH sensor during uncoating process of virus endocytosis

K. Meng, Y. Huyan, Q. Liu, J. Li, Y. Xiang, G. Meng

This study identifies ASFV p72 trimers as pH-sensitive structures that depolymerize in acidic endosomal conditions, explaining the pH-dependent uncoating mechanism of ASFV.

bioRxiv · Jun 9, 2023 · PreprintMicrobiology

A host E3 ubiquitin ligase regulates Salmonella virulence by targeting an SPI-2 effector involved in SIF biogenesis

K. Meng, J. Yang, J. Xue, J. Lv, P. Zhu, L. Shi, S. Li

The paper identifies TRIM32 as a host E3 ubiquitin ligase that targets SseK3, an SPI-2 effector, to restrict Salmonella-induced filament biogenesis and replication.

bioRxiv · Aug 5, 2022Cell Biology

Nucleocapsid 203 mutations enhance SARS-CoV-2 immune evasion

X. Lin, W. Xue, Y. Zhang, B. Fu, J. Trimpert, N. Xing, D. Kunec, W. Tang, Y. Xiao, K. Meng, S. Shi, H. Wu, G. Meng, Z. Zhu

This study shows that the nucleocapsid 203 mutation, combined with spike L452R, enhances SARS-CoV-2 immune evasion and fitness, contributing to the dominance of variants like Delta and Omicron.

bioRxiv · Dec 20, 2021 · PreprintMicrobiology

Nucleocapsid mutation R203K/G204R increases the infectivity, fitness and virulence of SARS-CoV-2

H. Wu, N. Xing, K. Meng, B. Fu, W. Xue, P. Dong, Y. Xiao, G. Liu, H. Luo, W. Zhu, X. Lin, G. Meng, Z. Zhu

This study shows that the N protein mutations R203K/G204R increase SARS-CoV-2 infectivity, replication, and virulence, contributing to its spread and disease severity.

bioRxiv · May 24, 2021Evolutionary Biology

Impact of Prior Infection on Protection and Transmission of SARS-CoV-2 in Golden Hamsters

C. Zhang, Z. Guo, N. Li, H. Cui, K. Meng, L. Liu, L. Zhao, S. Zhang, C. Qin, J. Liu, Y. Gao, C. Zhang

This study shows prior SARS-CoV-2 infection in golden hamsters provides partial protection but not sterilizing immunity, and virus can still be transmitted between infected and naive animals through direct contact.

bioRxiv · Jan 30, 2021 · PreprintMicrobiology

Prevailing role of mucosal immunoglobulins and B cells in teleost skin immune responses to bacterial infection

X. Zhang, Y. Yu, H. Xu, Z. Huang, X. Liu, J. Cao, K. Meng, Z. Wu, G. Han, M. Zhan, L. Ding, W. Kong, N. Li, F. Takizawa, O. Sunyer, z. xu

This study shows that IgT is the main immunoglobulin induced in trout skin mucosa during bacterial infection, with SALT serving as a key inductive site.

bioRxiv · Sep 21, 2020Immunology

Crystal structure of Senecavirus A 3C protease

K. Meng, L. Zhang, G. Meng

This study determines the crystal structure of Senecavirus A 3C protease at 1.9 Å resolution, revealing structural differences in the binding groove that may influence cleavage efficiency.

bioRxiv · Feb 21, 2020 · PreprintMicrobiology

A common problem in the purification of calicivirus raised by molecular sieving: balance between purification and loss of viral particles

Z. Qu, H. Kang, C. Cui, K. Meng, X. Zhang, L. Qu, G. Meng

This study evaluates the impact of molecular sieving on Feline Calicivirus stability using cryo-EM and develops a scoring system to assess purification effects.

bioRxiv · Feb 4, 2020 · PreprintMicrobiology

Expression and purification of African Swine Fever virus p72 trimers as subunit vaccine candidate

K. Meng, Y. Zhang, W. Zhu, Y. Xiang, G. Meng

The paper withdraws its manuscript due to invalid results and intends to revise the technical approach and interpretation.

bioRxiv · Jan 30, 2020 · PreprintMicrobiology

Tissue mechanics controls T-cell activation and metabolism

K. Meng, F. S. Majedi, T. J. Thauland, M. Butte

This study shows that tissue mechanics control T-cell activation and metabolism by regulating YAP-dependent NFAT nuclear translocation, affecting T-cell responses in viral infections and autoimmune diabetes.

bioRxiv · Mar 18, 2019Immunology