D. Yao

EGCG-modified bone graft to modulate the recruitment of M1 macrophage and alleviate the forming of fibrous capsule

This paper modifies bone grafts with EGCG to reduce fibrous capsule formation and improve macrophage recruitment and cell viability.

Death-seq identifies regulators of cell death and senolytic therapies

Death-seq identifies enhancers of cell death and senolytic therapies through a CRISPR screen, revealing synergistic combinations that clear senescent cells without thrombocytopenia.

Differential Binding Kinetics for Evaluating Immune Checkpoint Inhibitors in Serum

This study measures binding kinetics of immune checkpoint inhibitors in serum using GMR biosensors and compares them to label-free methods, finding serum affects off-rates and pharmacological modeling.

An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput screens

The paper develops HiLITR, a tool to study protein trafficking by linking localization to reporter gene expression, and identifies genes affecting mitochondrial and ER membrane protein trafficking.

Phytophthora sojae effector Avr1d functions as E2 competitor and inhibits ubiquitination activity of GmPUB13 to facilitate infection

This study identifies Avr1d as a Phytophthora sojae effector that inhibits GmPUB13 E3 ligase activity by competing with E2 ubiquitin conjugating enzymes, stabilizing the susceptibility factor and facilitating infection.

Human H-ferritin presenting RBM of spike glycoprotein as potential vaccine of SARS-CoV-2

This paper describes the design of a fusion protein using human ferritin to present the SARS-CoV-2 spike glycoprotein RBM, suggesting it as a potential vaccine candidate.