Author

F. You

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2 Microbiology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

Y. Zhao· 4 shared Z. Zhang· 4 shared D. Yang· 3 shared J. Li· 3 shared L. Cao· 3 shared X. Guo· 3 shared X. Wang· 3 shared Y. Luo· 3 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersImmunology

Y. Zhao

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Collateral cleavage of 28s rRNA by RfxCas13d causes death of mice

Y. Li, J. Xu, X. Guo, Z. Li, L. Cao, S. Liu, Y. Guo, G. Wang, Y. Luo, Z. Zhang, X. Wei, Y. Zhao, T. Liu, X. Wang, H. Xia, , F. You

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

bioRxiv · Jan 17, 2022 · PreprintBioengineering

Inhibiting ACSL1 related ferroptosis restrains MHV-A59 infection

H. Xia, Z. Zhang, F. You

This study shows inhibiting ferroptosis reduces MHV-A59 infection by suppressing viral propagation and inflammation.

bioRxiv · Oct 14, 2021 · PreprintMicrobiology

SAFA facilitates chromatin opening of immune genes through interacting with nascent antiviral RNAs

L. Cao, Y. Li, Y. Luo, X. Guo, S. Li, Z. Zhang, F. Gao, Q. Zhang, X. Ji, X. Gao, Y. Wang, Y. Zhao, F. You, S. Liu, J. Li

This study shows SAFA interacts with antiviral RNAs to open chromatin and enhance immune gene expression during viral infection.

bioRxiv · Jul 6, 2021 · PreprintImmunology

SARS-CoV-2 spike protein interacts with and activates TLR4

Y. Zhao, M. Kuang, X. Wang, F. You

This study identifies SARS-CoV-2 spike protein as a direct activator of TLR4 signaling in immune cells, leading to sepsis-related inflammation.

bioRxiv · Dec 18, 2020Immunology

Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy

L. Yang, T. Geng, G. Yang, J. Ma, L. Wang, H. Ketkar, D. Yang, T. Lin, J. Hwang, S. Zhu, Y. Wang, J. Dai, F. You, G. Cheng, A. Vella, , P. WANG

This study shows that MSR1 restricts Chikungunya virus infection by activating autophagy through interactions with ATG12 and the ATG5-ATG12-ATG16L1 complex.

Communications Biology · Oct 8, 2020Peer-reviewedMicrobiology

Small molecules inhibit SARS-COV-2 induced aberrant inflammation and viral replication in mice by targeting S100A8/A9-TLR4 axis

Q. Guo, Y. Zhao, J. Li, J. Liu, C. Qin, X. Wang, F. You, X. Guo, Z. Zhang, L. Cao, Y. Luo, X. Wang, X. Wei, L. Chen, L. Bao, , R. Gao

bioRxiv · Sep 9, 2020 · PreprintImmunology

A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil

J. Zhang, S. Zhang, Q. Shi, T. Allen, F. You, D. Yang

This paper identifies dimethylfasudil as a synthetic lethal compound for MYC-overexpressing cells through a high-content screen, showing its efficacy in rodent and human cell lines.

bioRxiv · Oct 10, 2019Cancer Biology

The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin1/Atg6-mediated lethal autophagy in polyploid cells

J. Zhang, S. Zhang, F. Wu, Q. Shi, T. Allen, F. You, D. Yang

The paper shows Bcl-2 and Bcl-xL reduce autophagic cell death in polyploid cells treated with Aurora-B kinase inhibitors, contributing to resistance to these drugs.

bioRxiv · Jun 27, 2019Cancer Biology