Author

F. Link

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Assay:bulk RNA-seq· 4 Organism:human· 4 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Assay:imaging· 2

Frequent Co-Authors

S. Dooley· 4 shared S. Wang· 4 shared Y. Yao· 4 shared C. Shao· 3 shared H. Ding· 3 shared H. Liu· 3 shared M. Ebert· 3 shared R. Liebe· 3 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCell Biology

S. Dooley

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6 papers

Recent·Most cited

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

Y. Li, C. Huang, W. Fan, S. Hammad, L. Berger, C. Geraud, Y. Yao, F. Link, C. Tong, Z. C. Nwosu, P. Erdoesi, W. Pioronska, K. Gould, C. Meyer, R. Feng, , S. Wang

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

bioRxiv · Feb 17, 2024 · PreprintCell Biology

The actomyosin system is essential for the integrity of the endosomal system in bloodstream form Trypanosoma brucei

F. Link, S. Jung, X. Malzer, F. Zierhut, A. Konle, A. Borges, C. Batters, M. Weiland, M. Poellmann, A. B. Nguyen, J. Kullmann, C. Veigel, M. Engstler, B. Morriswood

This study investigates the role of the actomyosin system in maintaining endosomal integrity in Trypanosoma brucei using imaging and biochemical assays.

bioRxiv · Jan 29, 2024Cell Biology

Retinoic acid generates a beneficial microenvironment for liver progenitor cell activation in acute liver failure

S. Wang, F. Link, S. Munker, W. Wang, R. Feng, R. Lieber, Y. Li, Y. Yao, H. Liu, C. Shao, M. Ebert, H. Ding, S. Dooley, H. Weng, S. Wang

This study shows retinoic acid secreted by activated hepatic stellate cells promotes liver progenitor cell activation in acute liver failure, improving patient outcomes.

bioRxiv · Jan 23, 2024Cell Biology

ECM1 Attenuates Hepatic Fibrosis by Interfering with Mediators of Latent TGF-β1 Activation

F. Link, Y. Li, J. Zhao, S. Munker, W. Fan, Z. Nwosu, Y. Yao, S. Wang, C. Huang, S. Hammad, R. Liebe, H. Liu, C. Shao, C. Gao, B. Sun, , S. Wang

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

bioRxiv · Dec 12, 2023Cell Biology

The interplay of TGF-β1 and cholesterol orchestrating hepatocyte cell fate, EMT, and signals for HSC activation

S. Wang, F. Link, M. Han, R. Chaudhary, A. Asimakopoulos, R. Liebe, Y. Yao, S. Hammad, A. Dropmann, M. Krizanac, C. Rubie, L. K. Feiner, M. Glanemann, M. Ebert, R. Weiskirchen, , S. Dooley

This study investigates how TGF-β1 and cholesterol interact to influence hepatocyte fate, EMT, and HSC activation in MASLD.

bioRxiv · Aug 14, 2023Cell Biology

Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes

F. Link, A. Borges, O. Karo, M. Jungblut, T. Mueller, E. Meyer-Natus, T. Krueger, S. Sachs, N. G. Jones, M. Morphew, M. Sauer, C. Stigloher, J. R. McIntosh, M. Engstler

The paper investigates the endosomal system in Trypanosoma brucei, revealing it as a continuous membrane system rather than distinct compartments, enabling rapid membrane trafficking.

bioRxiv · Jul 20, 2023Cell Biology