Author

S. Dooley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:development & morphogenesis· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Approach:statistical model· 2

Frequent Co-Authors

S. Wang· 5 shared C. Shao· 4 shared F. Link· 4 shared H. Ding· 4 shared H. Liu· 4 shared R. Liebe· 4 shared Y. Li· 4 shared Y. Yao· 4 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCell Biology

S. Wang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

Y. Li, C. Huang, W. Fan, S. Hammad, L. Berger, C. Geraud, Y. Yao, F. Link, C. Tong, Z. C. Nwosu, P. Erdoesi, W. Pioronska, K. Gould, C. Meyer, R. Feng, , S. Wang

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

bioRxiv · Feb 17, 2024 · PreprintCell Biology

Retinoic acid generates a beneficial microenvironment for liver progenitor cell activation in acute liver failure

S. Wang, F. Link, S. Munker, W. Wang, R. Feng, R. Lieber, Y. Li, Y. Yao, H. Liu, C. Shao, M. Ebert, H. Ding, S. Dooley, H. Weng, S. Wang

This study shows retinoic acid secreted by activated hepatic stellate cells promotes liver progenitor cell activation in acute liver failure, improving patient outcomes.

bioRxiv · Jan 23, 2024Cell Biology

ECM1 Attenuates Hepatic Fibrosis by Interfering with Mediators of Latent TGF-β1 Activation

F. Link, Y. Li, J. Zhao, S. Munker, W. Fan, Z. Nwosu, Y. Yao, S. Wang, C. Huang, S. Hammad, R. Liebe, H. Liu, C. Shao, C. Gao, B. Sun, , S. Wang

This study shows ECM1 prevents hepatic fibrosis by inhibiting TGF-β1 activation, with implications for developing safe anti-fibrotic therapies.

bioRxiv · Dec 12, 2023Cell Biology

The interplay of TGF-β1 and cholesterol orchestrating hepatocyte cell fate, EMT, and signals for HSC activation

S. Wang, F. Link, M. Han, R. Chaudhary, A. Asimakopoulos, R. Liebe, Y. Yao, S. Hammad, A. Dropmann, M. Krizanac, C. Rubie, L. K. Feiner, M. Glanemann, M. Ebert, R. Weiskirchen, , S. Dooley

This study investigates how TGF-β1 and cholesterol interact to influence hepatocyte fate, EMT, and HSC activation in MASLD.

bioRxiv · Aug 14, 2023Cell Biology

Insulin determines the effects of TGF-beta on HNF4alpha transcription and epithelial-to-mesenchymal transition in hepatocytes

R. Feng, C. Tong, T. Lin, H. Liu, C. Shao, Y. Li, C. Sticht, K. Kan, X. Li, R. Liu, S. Wang, S. Wang, S. Munker, H. Niess, C. Meyer, , H.-L. Weng

This study shows insulin prevents TGF-beta-induced EMT in hepatocytes by inhibiting SMAD2/3 binding to C/EBP and SNAI1 promoters, maintaining HNF4 expression.

bioRxiv · Jan 12, 2023 · PreprintCell Biology

Training induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability

I. A. Ely, E. J. Jones, T. B. Inns, S. Dooley, S. B. J. Miller, D. W. Stashuk, P. J. Atherton, B. E. Phillips, M. Piasecki

This study shows that force accuracy training reduces motor unit firing rate variability in the vastus lateralis, improving force tracking accuracy without increasing muscle strength.

bioRxiv · Feb 10, 2022Physiology