SSRI antidepressant citalopram reverses the Warburg effect to inhibit hepatocellular carcinoma by directly targeting GLUT1
F. Dong, K. He, S. Zhang, K. Song, L. Jiang, L. Hu, Q. Li, X.-L. Zhang, N. Zhang, B.-T. Li, L.-L. Zhu, J. Li, M. Feng, Y. Gao, J. Chen, , S.-H. Jiang
This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.
Cell Reports · Oct 1, 2024Peer-reviewedCancer Biology