Q. Ji

TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis

This study shows TERT promotes thyroid cancer dedifferentiation and progression by enhancing ribosome biogenesis, and inhibiting rRNA synthesis can reverse this process.

Therapeutic immunization against Helicobacter pylori infection in BALB/c mice induced by a multi-epitope vaccine based on computer-aided design

This study develops and evaluates two multi-epitope vaccines against H. pylori using computer-aided design, showing they reduce bacterial colonization and stomach damage in infected mice.

Resurrection of human endogenous retroviruses during aging reinforces senescence

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

Embedding of exogenous B cell epitopes on the surface of UreB structure generates a broadly reactive antibody response against Helicobacter pylori

This study develops a multi-epitope chimeric antigen (MECU) that generates a broadly reactive antibody response against H. pylori and reduces stomach colonization in mice.

Identification and Evaluation of a Panel of Strong Constitutive Promoters in Listeria monocytogenes for Improving the Expression of Foreign Antigens

The paper identifies and evaluates strong constitutive promoters in Listeria monocytogenes to enhance foreign antigen expression, finding P18 as the most effective.

Decoding the single-cell landscape and intercellular crosstalk in the transplanted liver: a 4-dimension mouse model

This study maps the cellular dynamics and intercellular interactions in a mouse liver transplant model using single-cell RNA sequencing and CyTOF, revealing recipient cell dominance and macrophage-driven metabolic remodeling.

Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

iTRAQ-Based Proteomic Profiling of PLC-Mediated Expression of 20E-Induced Protein in Apolygus lucorum (Meyer-Dür)

This study uses iTRAQ proteomics to identify 20E and PLC inhibitor-regulated proteins in Apolygus lucorum, revealing shared and distinct DEPs and their involvement in metabolic and signaling pathways.

A novel copper-sensing two-component system for activating Dsb genes in bacteria

The paper identifies a novel copper-sensing two-component system, DsbRS, in Pseudomonas aeruginosa that activates the dsbDEG operon involved in copper resistance.

Potentiating the anti-tumor response of tumor infiltrated T cells by NAD+ supplementation

NAD+ supplementation enhances T cell activation and tumor-killing capacity in immunotherapies.

Decoding mRNA translatability and stability from 5'UTR

The paper uses synthetic mRNA libraries to study 5'UTR sequence elements affecting mRNA translatability and stability in mammalian cells, identifying regulatory features and decay pathways.

Analysis of metagenome-assembled genomes from the mouse gut microbiota reveals distinctive strain-level characteristics

This study identifies strain-level features of the mouse gut microbiota using metagenome-assembled genomes, revealing distinct genomic and functional characteristics compared to human gut microbes.

Earliest-known intentionally deformed human cranial fossil from Asia and the initiation of hereditary hierarchy in the early Holocene

The paper reports an ancient cranial deformation fossil from Northeastern China, suggesting early hereditary hierarchy in non-agricultural societies during the early Holocene.