Author

L. Ouyang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:Drosophila· 1 Assay:long-read sequencing· 1

Frequent Co-Authors

H. Pei· 2 shared H. Wei· 2 shared H. Ye· 2 shared J. Yang· 2 shared L. Chen· 2 shared L. Niu· 2 shared Q. Chen· 2 shared W. Yan· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

H. Pei

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Transcription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape

B. Santinello, R. Sun, A. Amjad, S. J. Hoyt, L. Ouyang, C. Courret, R. Drennan, L. Leo, A. M. Larracuente, L. Core, R. J. O'Neill, B. G. Mellone

This study investigates Jockey-3 retroelement transcription and RNA localization at centromeres in Drosophila, showing its correlation with CENP-A and potential role in centromere maintenance.

bioRxiv · Jan 14, 2024Cell Biology

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

J. Yang, Y. Yu, Y. Li, W. Yan, H. Ye, L. Niu, M. Tang, Z. Wang, Z. Yang, H. Pei, H. Wei, M. Zhao, J. Wen, L. Yang, L. Ouyang, , L. Chen

The paper identifies a novel binding site on α-tubulin and shows that cevipabulin binding to this site induces tubulin degradation.

Science Advances · May 21, 2021Peer-reviewedCell Biology

A new role of low barrier hydrogen bond in mediating protein stability by small molecules

J. Yang, Y. Li, Q. Qiu, R. Wang, W. Yan, Y. Yu, L. Niu, H. Pei, H. Wei, L. Ouyang, H. Ye, D. Xu, Y. Wei, Q. Chen, L. Chen

This study identifies a novel role of low barrier hydrogen bonds in promoting selective tubulin degradation through small molecule interactions.

bioRxiv · May 9, 2021 · PreprintBiochemistry

Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p

Y. Tong, N. Sun, X. Wang, Q. Wei, Y. Zhang, R. Huang, Y. Pu, H. Dai, B. Ren, G. Pei, F. Song, G. Zhu, X. Wang, X. Xia, X. Chen, , G. Alterovitz

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

bioRxiv · Jun 26, 2020Microbiology