B. Ren

Inhibition of serine racemase prevents diabetic retinopathy

This study shows that inhibiting serine racemase with L-ABH prevents diabetic retinopathy by protecting retinal cells and maintaining glucose homeostasis in diabetic mice.

The Hippo/YAP Pathway Mediates the De-differentiation of Corneal Epithelial Cells into Functional Limbal Epithelial Stem Cells In Vivo

This study shows corneal epithelial cells can de-differentiate into functional limbal epithelial stem cells in vivo, mediated by the Hippo/YAP pathway, offering a new approach for treating limbal stem cell deficiency.

Muscone-specific olfactory protein reveals the putative scent-marking pheromone in the Sunda pangolin (Manis javanica)

This study identifies muscone as a potential male-specific scent-marking pheromone in Sunda pangolins through functional expression of odorant-binding proteins and behavioral assays.

Cell-type-specific 3D-genome organization and transcription regulation in the brain

The paper investigates 3D-genome organization and transcription regulation in distinct cell types of the mouse brain, finding cell-type-specific nuclear architecture and chromatin compartmentalization correlated with transcriptional activity and MeCP2 regulation.

Lepidoptera proboscis pollens are mainly derived from nectar

The study shows that pollens on the proboscis of Lepidoptera are mainly from nectar, supporting their role in pollination and pollen germination on stigmas.

Low photosynthetic rate under low light stress inhibited sucrose distribution and transportation to grain

This study shows low light stress reduces summer maize yield by decreasing leaf photosynthetic rate, impairing sucrose transport to grains, and creating a sugar concentration gradient that inhibits sucrose output.

Chlamydomonas Mutants Null for Chloroplast Triose Phosphate Transporter3 are Metabolically Compromised and Light Sensitive

This study identifies CreTPT3 as a critical chloroplast transporter in Chlamydomonas, showing its role in metabolite transport, oxidative stress prevention, and subfunctionalization with CreTPT2.

PKD-1 Signaling Is Required for the Maintenance of CSCs with Epithelial-mesenchymal Plasticity in Pancreatic Neuroendocrine Tumors

This study shows PKD-1 signaling is essential for maintaining CSCs with epithelial-mesenchymal plasticity in pNETs, suggesting it as a therapeutic target.

Improving the Virtual Trichrome Assessment through Bridge Category Models

This paper assesses Virtual Trichrome technologies using Bridge Category Models to account for bridge ratings in Fibrosis staging of NASH tissue.

Estimating the Inter- and Intra-Rater Reliability for NASH Fibrosis Staging in the Presence of Bridge Ordinal Ratings with Hierarchical Bridge Category Models

This paper develops hierarchical Bayesian models to assess inter- and intra-rater reliability for NASH fibrosis staging, showing improved precision over ad hoc methods.

Single-cell transcriptome analysis reveals mesenchymal stem cells in cavernous hemangioma

This study identifies mesenchymal stem cells in cavernous hemangioma using scRNA-seq and proposes their origin from epiblast stem cells, along with new cell types and molecular mechanisms involved in tumor formation and immune responses.

Bridge Category Models: Development of Bayesian Modelling Procedures to Account for Bridge Ordinal Ratings for Disease Staging

The paper develops Bayesian models to handle bridge ordinal ratings in disease staging and shows they reduce bias and precision loss in models.

Endothelial SIRPα signaling controls thymic progenitor homing for T cell regeneration and antitumor immunity

This study identifies endothelial SIRPα signaling as critical for thymic progenitor homing, T cell regeneration, and antitumor immunity through CD47-SIRP interactions and VE-cadherin endocytosis.

MLL3/MLL4 Histone Methyltranferase Activity Dependent Chromatin Organization at Enhancers during Embryonic Stem Cell Differentiation

This study investigates how MLL3/MLL4 histone methyltransferase activity influences enhancer-promoter contacts and gene activation during mouse embryonic stem cell differentiation.

Discovery and Functional Characterization of Pro-growth Enhancers in Human Cancer Cells

The paper identifies and characterizes pro-growth enhancers in cancer cells using CRISPR screens, finding lineage-specific enhancers associated with poor prognosis and potential therapeutic targets.

{-}Multivariable Association Discovery in Population-scale Meta-omics Studies

This paper introduces MaAsLin 2, a method for analyzing multivariable associations in microbial multi-omics data, and applies it to reveal new insights into inflammatory bowel disease.

The dynamic landscape of parasitaemia dependent intestinal microbiota shifting at species level and the correlated gut transcriptome during Plasmodium yoelii infection

This study examines how parasitaemia levels during Plasmodium yoelii infection in mice affect intestinal microbiota composition and correlate with immune cell development.

LPA/PKD-1 signaling promotes development of arteriolar niche that supports self-renewal of breast cancer stem cells and stemness

Alisertib exerts KRAS allele specific anticancer effects in colorectal cancer

This study investigates how Alisertib affects KRAS mutations in colorectal cancer cells, showing allele-specific effects on RAS signaling and cell death mechanisms.

SpRY greatly expands the genome editing scope in rice with highly flexible PAM recognition

This study shows SpRY expands CRISPR editing in rice by recognizing diverse PAMs, enabling efficient genome modification across various loci.

A Large-Scale Internal Validation Study of Unsupervised Virtual Trichrome Staining Technologies on Non-alcoholic Steatohepatitis Liver Biopsies

This study validates the use of GANs for virtual trichrome staining of NASH liver biopsies, showing high correlation with real stains and clinical outcomes.

Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

DNA replication-mediated error correction of ectopic CENP-A deposition maintains centromere identity

The paper shows DNA replication removes CENP-A from chromosome arms, preserving centromere identity by maintaining CENP-A at centromeres.

MITA couples with PI3K to regulate actin reorganization during BCR activation

This study shows MITA regulates BCR signaling through actin reorganization via the PI3K pathway, affecting B cell differentiation and autoimmune disease.