P. Tong

β-catenin inhibition disrupts the homeostasis of osteogenic/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of femoral head

This study shows that β-catenin inhibition disrupts osteogenic/adipogenic differentiation in bone marrow mesenchymal cells, contributing to glucocorticoid-induced osteonecrosis of the femoral head.

Endosome-ER Interactions Define a Cellular Energy Landscape to Guide Cargo Transport

The paper analyzes EGFR-endosome transport dynamics in living cells, revealing spatially regulated 2-state motion and proposing an ER-driven free-energy landscape model for cargo transport.

Depletion of collagen IX alpha2 interferes osteochondral homeostasis of the knee joint which ultimately causing osteoarthritis-like articular cartilage damage

This study shows that Col92 deficiency in mice leads to osteochondral homeostasis disruption and osteoarthritis-like cartilage damage in the knee joint.

Structural and functional characteristics of SARS-CoV-2 Omicron subvariant BA.2 spike

This study characterizes the structural, functional, and antigenic properties of SARS-CoV-2 Omicron BA.2 spike protein and compares its replication efficiency with previous variants.

Structural and functional impact by SARS-CoV-2 Omicron spike mutations

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

Differential antibody dynamics to SARS-CoV-2 infection and vaccination

This study compares antibody durability and breadth after SARS-CoV-2 infection and vaccination, finding that infection-induced antibodies show greater long-term stability and cross-variant breadth.

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

This study compares the structure, function, and antigenicity of the SARS-CoV-2 Delta variant's spike protein with other variants, showing its enhanced membrane fusion and transmissibility.

Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants

This study reports cryo-EM structures of SARS-CoV-2 variants B.1.1.7 and B.1.351, revealing mutations that enhance infectivity and immune evasion.

Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike

The paper maps memory B cell receptors against SARS-CoV-2 spike variants, identifying 7 mAb competition groups and their epitopic regions, and shows their cross-reactivity and neutralization properties.

Inhibition of nonsense-mediated decay rescues functional p53β/γ isoforms in MDM2-amplified cancers

The paper shows that inhibiting nonsense-mediated decay increases expression of p53β/γ isoforms, which are resistant to MDM2 degradation, thereby restoring p53 function in cancers with MDM2 amplification, HPV infection, or specific p53 mutations.

Large domains of heterochromatin direct the formation of short mitotic chromosome loops

The paper shows that heterochromatin in mouse and human cells forms smaller chromatin loops during mitosis compared to euchromatic regions.