C. Xi

Identification of Glucosidase II that regulates STIM1 activation dynamics

This study identifies glucosidase II as a regulator of STIM1 activation dynamics by modulating Ca2+ binding affinity and influencing store-operated Ca2+ entry.

Discovery and characterization of highly potent and selective covalent inhibitors of SARS-CoV-2 PLpro

This study identifies and characterizes two covalent PLpro inhibitors, HUP0109 and DX-027, as potential treatments for SARS-CoV-2.

Deep learning identifies pathological abnormalities predictive of graft loss in kidney transplant biopsies

This paper develops a deep learning model to quantify pathological features in kidney transplant biopsies, showing improved prediction of graft loss compared to clinical and Banff scores.

Variations of gut microbiome profile under different storage conditions and preservation periods: A multi-dimensional evaluation

This study evaluates how different storage conditions, preservation periods, and sequencing platforms affect gut microbiome profiles using 16S rRNA gene sequencing.

Modeling the emergence of antibiotic resistance in the environment: an analytical solution for the minimum selection concentration

The paper develops a model to predict the minimum selection concentration of antibiotics using MIC and selection coefficient, showing MSC can be much lower than MIC.