S. Ma

This study identifies two small-molecule inhibitors of LpxA, revealing distinct inhibition mechanisms and highlighting compound 2's improved properties for antibacterial development.

The paper uses spatial transcriptomics to model metabolic gene expression in prostate cancer, identifying spatially distinct metabolic vulnerabilities and potential drug targets.

This paper identifies a novel mechanism of drug tolerance in M. tuberculosis through phase variation in the glpK gene, showing reversible frameshift mutations that contribute to treatment failure and relapse.

This study improves the specificity of adenine base editor ABE7.10 by replacing SpCas9 with high-fidelity Cas9 variants, showing reduced off-target activity in four test sites.

This study characterizes the structural and biochemical interactions of the MazEF-mt9 TA system in M. tb, revealing its cognate and heterologous antitoxin binding and its role in stress adaptation.

This study compares bacterial composition and functional differences between cancerous and noncancerous ovarian tissues using 16S rRNA sequencing and metagenomic predictions.

The paper investigates the spatial organization of S-layer biogenesis in Clostridium difficile, finding that SlpA secretion is delocalized while S-layer formation occurs at sites of cell wall synthesis.

The paper identifies a common Piezo1 variant in African populations that causes xerocytosis and reduces Plasmodium infection.